DNA UV damage-related control of ribonucleotide reductase : possible relationship to mutagenesis and the incidence of and attitudes toward skin cancer in several western nations Public Deposited

http://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/c534fq92w

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Two strains of Escherichia coli were studied to determine the effect of constitutive expression of the SOS DNA damage repair response on the activity of ribonucleotide reductase. Activity of the reductase and cellular deoxynucleoside triphosphate (dNTP) pools were both determined before and after exposure of the cells to ultraviolet radiation. The experiments showed no significant difference in enzyme activity or cellular dNTP pool levels between normal E. coli and cells constitutively expressing the SOS DNA damage repair response. Although the SOS response and proportional accumulation of dNTPs both lead to DNA mutation, the occurrence of the latter after a damage event is not controlled or promoted by the first. Cellular DNA damage due to ultraviolet light is of concern to humans because it can lead to skin cancer. In addition to laboratory research, the topic of skin cancer in the Western world was also examined. Data from cancer indices and journal articles were used to analyze the incidence of non-melanoma and malignant melanoma skin cancers. Studies analyzing the awareness of skin cancer amongst the populations of several Western nations were also discussed. The attitudes of people toward skin cancer and sun exposure were found not to correlate with statistical risk of developing the cancer.
Resource Type
Date Available
Date Issued
Degree Level
Degree Name
Degree Grantor
Advisor
Committee Member
Non-Academic Affiliation
Keyword
Subject
Rights Statement
Language
File Format
File Extent
  • 128512 bytes
Replaces
Additional Information
  • description.provenance : Submitted by Heather Boren (borenh) on 2006-07-05T21:45:38Z No. of bitstreams: 1 Thesis2.0.doc: 128512 bytes, checksum: de00afa90e84d4935f5b62bc6dbacf80 (MD5)
  • description.provenance : Made available in DSpace on 2006-07-07T15:04:53Z (GMT). No. of bitstreams: 1 Thesis2.0.doc: 128512 bytes, checksum: de00afa90e84d4935f5b62bc6dbacf80 (MD5)

Relationships

In Administrative Set:
Last modified: 07/27/2017

Downloadable Content

Download file
Citations:

EndNote | Zotero | Mendeley

Items