Investigating compounds to target glioblastoma progression Public Deposited

http://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/d791sj17d

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  • Glioblastoma multiforme is a devastating primary brain tumor with a median five year survival rate of less than 5%. It is a cancer that is resistant to current cancer treatments, such as surgery and chemotherapy, as well as one that is prone to recurrence after surgical removal. This highlights the importance of discovering or improving upon treatments for glioblastoma. Thus, the goal of this research is to investigate the anti-cancer properties of two compounds: zinc-oxide nanoparticles and synthetic calpain-2 inhibitors. In the first part of this research, the xCELLigence system was used to assess the anti-proliferative and cytotoxic effects of zinc-oxide nanoparticles in a cell culture model of glioblastoma. From the results gathered, it was concluded that, although a 200 uM solution of ZnO NP dispersed in DMSO had a significant cytotoxic effect on GBM cells, zinc-oxide nanoparticles would not make an effective glioblastoma treatment at this time. In the second part of this research, an embryonic zebrafish xenograft model of GBM was used to test the anti-invasive properties of synthetic calpain-2 inhibitors. Preliminary results from this model are inconclusive and necessitate further testing. Future work regarding both parts of this research are also discussed.
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