Preparation of Tacrolimus-loaded Biodegradable Nanoparticles for Sustained Drug Delivery Public Deposited

http://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/db78tf029

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  • Tacrolimus is an immunosuppressant drug approved by the FDA for the prevention of organ transplant rejection. However, the use of this drug is hindered by its narrow therapeutic window and extreme insolubility in water. Due to these properties, the currently used tacrolimus preparations must be administered once or twice daily to minimize peak and trough effects and maintain a therapeutic concentration in the subject. In this study, biodegradable polymeric nanoparticles are explored as an alternative delivery vehicle. First, a method was developed for formulating tacrolimus-loaded nanoparticles. Seven different polymers were used to prepare the nanoparticles, and their size, polydispersity index (PDI), and drug loading was quantified. The stability of the best formulations was assessed at room temperature and in a refrigerated environment. The drug release profiles of these formulations were also studied and plotted. Though these nanoparticles did not demonstrate significant extended release properties, they were successful in increasing the tacrolimus solubility in water by over a factor of 100 compared to the free drug. Furthermore, the results of this study reflect the importance of PEGylated polymers for developing tacrolimus-loaded nanoparticles.
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  • description.provenance : Submitted by Reid Kinser (kinserre@oregonstate.edu) on 2016-05-23T01:23:55Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: bb87e2fb4674c76d0d2e9ed07fbb9c86 (MD5) KinserReidW2016.pdf: 1150416 bytes, checksum: 5ffdb3c80b62265ac547ea42235f3982 (MD5)
  • description.provenance : Made available in DSpace on 2016-05-24T16:13:57Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: bb87e2fb4674c76d0d2e9ed07fbb9c86 (MD5) KinserReidW2016.pdf: 1150416 bytes, checksum: 5ffdb3c80b62265ac547ea42235f3982 (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2016-05-24T16:13:56Z (GMT) No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: bb87e2fb4674c76d0d2e9ed07fbb9c86 (MD5) KinserReidW2016.pdf: 1150416 bytes, checksum: 5ffdb3c80b62265ac547ea42235f3982 (MD5)

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