Superior Anti-tumor Activity Exhibited From a Gemcitabine Prodrug Incorporated into Lecithin-Based Nanoparticles Public Deposited

http://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/ht24wm403

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  • Cancer is class of diseases that has great diversity and unfortunately is one of the leading causes of death in the United States. Chemotherapy remains an important cancer treatment modality, and superior chemotherapeutic drugs are constantly being sought. Gemcitabine is an anti-tumor chemotherapeutic drug and it is the first line of defense in treating pancreatic cancer, as well as, used in combination therapy for non-small cell lung, ovarian, and metastatic breast cancers. Patients with cancer, specifically pancreatic carcinoma, have a high mortality rate which highlights the poor anti-tumor activity of gemcitabine. The anti-tumor activity of gemcitabine shows needed improvement due to its short half-life and low specificity in patients. The objective of this study is to utilize lecithin-based nanoparticles (NP) as a delivery system for a lipophilic gemcitabine prodrug. From this current study, a maximum drug concentration of 5 mg/ml was achieved into nanoparticles, thereby improving anticancer activity of gemcitabine. Keywords: Gemcitabine, nanoparticles, chemotherapy
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  • description.provenance : Submitted by Wanda Crannell (crannelw@hort.oregonstate.edu) on 2009-09-09T17:18:47Z No. of bitstreams: 3 Poster Presentation Michael Sandoval.pdf: 477863 bytes, checksum: d25f478bb649b32f6a405053fca96d7f (MD5) Thesis Seminar Michael Sandoval.ppt: 4004864 bytes, checksum: 4cc7bdcce849998317ca418d60d8ece3 (MD5) Michael Sandoval BRR Thesis.pdf: 401700 bytes, checksum: c9702bcfcc868b6048abe6e2825e8e60 (MD5)
  • description.provenance : Made available in DSpace on 2009-09-10T12:54:13Z (GMT). No. of bitstreams: 3 Poster Presentation Michael Sandoval.pdf: 477863 bytes, checksum: d25f478bb649b32f6a405053fca96d7f (MD5) Thesis Seminar Michael Sandoval.ppt: 4004864 bytes, checksum: 4cc7bdcce849998317ca418d60d8ece3 (MD5) Michael Sandoval BRR Thesis.pdf: 401700 bytes, checksum: c9702bcfcc868b6048abe6e2825e8e60 (MD5)
  • description.provenance : Approved for entry into archive by Linda Kathman(linda.kathman@oregonstate.edu) on 2009-09-10T12:54:13Z (GMT) No. of bitstreams: 3 Poster Presentation Michael Sandoval.pdf: 477863 bytes, checksum: d25f478bb649b32f6a405053fca96d7f (MD5) Thesis Seminar Michael Sandoval.ppt: 4004864 bytes, checksum: 4cc7bdcce849998317ca418d60d8ece3 (MD5) Michael Sandoval BRR Thesis.pdf: 401700 bytes, checksum: c9702bcfcc868b6048abe6e2825e8e60 (MD5)

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