Honors College Thesis
 

Effects of Xanthohumol on Biomarkers of Metabolic Syndrome in Obese Rats

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https://ir.library.oregonstate.edu/concern/honors_college_theses/ns064783z

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  • Flavonoids are a large family of compounds synthesized by plants that have a common chemical structure. It is believed that the health effects of fruits and vegetables are primarily due to dietary flavonoids content. Current research indicates that dietary flavonoids show promise for mitigating and/or preventing chronic conditions associated with metabolic syndrome. Xanthohumol (XN) is the major prenylated flavonoid of the female inflorescences (cones) of the hop plant (Humulus lupulus). Recent findings suggest that XN may impart health benefits by lowering plasma cholesterol and triglycerides level. It is important to analyze the different effects of XN on the major risk factors for metabolic syndrome such as cardiovascular disease, obesity, and type II diabetes. We examined the potential role of dietary supplementation of XN for the prevention of metabolic syndrome using the obese rat Zucker fa/fa model. The rats were fed XN using a high fat diet in the first three weeks to induce obesity, and a normal fat diet in the last three weeks. We found that XN decreases plasma glucose and insulin levels and body weight gain in obese male rats, suggesting that XN may be beneficial for preventing metabolic syndrome.
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