Effect of Perinatal Low Protein Diet on the Expression of Renal Organic Cation Transporter 2 and Novel Organic Cation Transporter 2 in Adult Rats Public

http://ir.library.oregonstate.edu/concern/honors_college_theses/p8418q243

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  • Studies have established that there is a greater risk for onset of adult metabolic syndrome disease such as diabetes mellitus, hypertension, hyperlipidemia, and obesity in subjects born with low birth weight (LBW). Undernourished fetuses make adaptions that result in structurally, morphologically, and functionally altered organs. In terms of drug pharmacokinetics, the alterations of organs that are associated with absorptions, distribution, metabolism, and excretion of drugs seen in LBW animals are significant. There is a possibility for LBW-induced susceptibility to adverse drug reactions or altered drug therapy which makes the study of renal drug transporters important for predicting drug dose and dosing regimen for optimal dosing pharmacotherapy. The purpose of this study is to evaluate the effect of LBW on the mRNA and protein expression of Organic Cation Transporter-2 (OCT2) and Novel Organic Cation Transporter -2 (OCTN2) in young (Day28 old), adolescent (Day65 old), and adult (Day150 old) rats. In this study, the maternal low protein diet (LPD) was used. OCT2 and OCTN2 mRNA levels were significantly altered in the LBW Day150 female offspring. Western blotting of various membrane fractions indicated slight differences in protein level expression of these transporters. Further studies can provide insights into how altered kidney development through LBW can affect drug pharmacokinetics.
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