Permeability of Various Thyroid Hormone Derivatives and Discovery of a Novel Metabolite Public

http://ir.library.oregonstate.edu/concern/honors_college_theses/rb68xd79g

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  • In this investigation, six different endogenous thyroid hormone derivatives—T₄, T₃, TA₄, TA₃, T₁-Amine, and N-Acetylated T₁-Amine—were tested to gain insight into their permeability coefficients and efflux ratios across a monolayer of Madin-Darby Canine Kidney (MDCK II) cells. The results indicate that T₃ and T₄ were unable to traverse the membrane due to lack of compatible membrane bound transporters, which supports that the transport of both T₃ and T₄ into their cellular targets relies on membrane proteins. The data also suggested that T₁-Amine and N-Acetylated T₁-Amine may cross the plasma membrane by an active transport mechanism, while the remaining derivatives express efflux ratios indicative of a passive diffusion mechanism. Incubating N-Acetylated T₁-Amine with MDCK II cells produced a novel metabolite, which was identified as a sulfated form of N-Acetylated T₁-Amine.
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