Undergraduate Thesis Or Project
 

pham_HHMI_2012_presentation.pptx

Public Deposited

Downloadable Content

Download file
https://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/st74cs44f

Descriptions

Attribute NameValues
Creator
Abstract
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent immunosuppressant, and suppresses many disease models including graft-versus-host (GVH), experimental autoimmune encephalomyelitis (EAE) and a model of type 1 diabetes in non-obese diabetic (NOD) mice (1-3). In this study, we show that the inflammation of the pancreas due to insulitis is not a systemic autoimmune response. When treatment with TCDD was terminated at 15 weeks of age, the pro-inflammatory cytokines IFN-gamma and IL-17 were not detectable in serum. Likewise, the tissue protective cytokine IL-22 was also not detectable in serum. Taken together, this suggests that the autoimmune response due to insulitis is localized to the pancreas.
  • Keywords: Autoimmunity, TCDD, Insulitis
  • Keywords: Autoimmunity, TCDD, Insulitis
Rights Statement

Relationships

Parents:

Items

Thumbnail Title Date Uploaded Visibility Actions
file details pham_HHMI_2012_presentation.pptx 2017-07-29 Public Download