Other Scholarly Content | Enhanced Protein Homeostasis Mechanisms in Naked Mole Rats Cells | ID: tb09j7042 | 蹄兔

Other Scholarly Content

Enhanced Protein Homeostasis Mechanisms in Naked Mole Rats Cells

公开 Deposited

下载PDF文件

Citeable URL: https://ir.library.oregonstate.edu/concern/defaults/tb09j7042

Descriptions

Attribute Name	Values
Creator	Pride, Harrison Coles, Alex Mochnick, Jillian Zhang, Yiqiang Buffenstein, Rochelle Hornsby, Peter J. Austad, Steve Richardson, Arlan Perez, Viviana I.
Abstract	Phylogenic studies suggest that cells from long-lived species are more resistant to a variety of stressors than short-lived species. However, there is little information on the cellular mechanisms that give rise to increased resistance to stress. Our previous studies have shown that liver proteins from a long-lived species have lower levels of protein ubiquitination which is associated with increased proteasome activity, suggesting that mechanisms of protein quality control could play a critical role in assuring longevity of long-lived species. In this study, we evaluated whether autophagy and heat shock chaperones proteins (HSPs) are associated with longevity in rodents using skin fibroblasts isolated from mice and naked mole rats (NMR); two species that are similar in body size but differ almost 10 fold in longevity. Our results indicate that macroautophagy induced by serum-starvation is significantly enhanced in NMR compared to mouse which correlates with an inhibition of the mTOR pathway and increased LC3 conversion. We also found that several HSPs (e.g., Hsp90, Hsp70, Hsp40, Hsp 27) were significantly higher at both basal and after heat shock conditions. These observations suggest that NMR, a long-lived species, has increased mechanisms to ensure protein quality (autophagy and HSPs) and support the idea that protein homeostasis could play an important role in promoting longevity.
Resource Type	Poster
Date Available	2013-05-31T17:42:04+00:00
Date Issued	2013-05-31
Degree Level	Bachelor's
Degree Name	Bachelor of Science (B.S.)
Advisor	Perez, Viviana
Academic Affiliation	Microbiology Biochemistry and Biophysics
Non-Academic Affiliation	Oregon State University. Undergraduate Research, Scholarship, and the Arts (URSA)
权利声明	In Copyright
Funding Statement (additional comments about funding)	Financial support was provided by Ellison Medical foundation (to both VP and RB), American Federation for Aging Research and The Glenn Foundation (RB).
Publisher	Oregon State University
Peer Reviewed	No
Language	English [eng]
Replaces	http://hdl.handle.net/1957/38802

关联

Parents:

This work has no parents.

属于 Collection:

Undergraduate Research, Scholarship, and the Arts (URSA)

单件

缩略图	标题	上传日期	公开度	行动
	DOH-2013-Harrison-2.pdf	07/21/2017	公开
	DOH-2013-Harrison.pptx	07/21/2017	公开