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  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent immunosuppressant, and suppresses many disease models including graft-versus-host (GVH), experimental autoimmune encephalomyelitis (EAE) and a model of type 1 diabetes in non-obese diabetic (NOD) mice (1-3). In this study, we show that the inflammation of the pancreas due to insulitis is not a systemic autoimmune response. When treatment with TCDD was terminated at 15 weeks of age, the pro-inflammatory cytokines IFN-gamma and IL-17 were not detectable in serum. Likewise, the tissue protective cytokine IL-22 was also not detectable in serum. Taken together, this suggests that the autoimmune response due to insulitis is localized to the pancreas.
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  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2013-06-07T21:40:43Z (GMT) No. of bitstreams: 3 license_rdf: 1232 bytes, checksum: bb87e2fb4674c76d0d2e9ed07fbb9c86 (MD5) pham_HHMI_2012_presentation.pdf: 616829 bytes, checksum: c888dc370215c37027577ec1c21141c9 (MD5) pham_HHMI_2012_presentation.pptx: 894039 bytes, checksum: c00cb552cf0158970c5ab43441e45e6c (MD5)
  • description.provenance : Rejected by Sue Kunda(sue.kunda@oregonstate.edu), reason: Hi, Tuan. Your ScholarsArchive@OSU submission has been rejected because you attached a CC0 1.0 Universal or Public Domain License to your work. These licenses means that you have "dedicated the work to the public domain by waiving all of your rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law. Others can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission." We strongly suggest that you don't attach either of these licenses. We're assuming you probably meant to add a Creative Commons licenses to your work so that others could use it, but you intended to retain your copyrights. Please re-submit* your work and choose "Creative Commons License" from the License Type drop down box. You'll then be asked two questions about how you want people to use your work. You can also choose "No Creative Commons License". *To re-submit your work, log into ScholarsArchive@OSU. Your rejected submission will be in your Submissions & Tasks work file. You can just resume the submission. All your information will still be in the form; you need to change only the CC License page. If you have any questions or concerns, please contact Sue Kunda: sue.kunda@oregonstate.edu OR 541-737-7262. Sue Kunda Digital Scholarship Librarian OSU Libraries & Press 121 The Valley Library Corvallis, OR 97331 sue.kunda@oregonstate.edu 541-737-7262 on 2013-06-07T17:41:14Z (GMT)
  • description.provenance : Made available in DSpace on 2013-06-07T21:40:43Z (GMT). No. of bitstreams: 3 license_rdf: 1232 bytes, checksum: bb87e2fb4674c76d0d2e9ed07fbb9c86 (MD5) pham_HHMI_2012_presentation.pdf: 616829 bytes, checksum: c888dc370215c37027577ec1c21141c9 (MD5) pham_HHMI_2012_presentation.pptx: 894039 bytes, checksum: c00cb552cf0158970c5ab43441e45e6c (MD5)
  • description.provenance : Submitted by Tuan Pham (phamtuan@onid.orst.edu) on 2013-06-06T17:53:15Z No. of bitstreams: 3 license_rdf: 1089 bytes, checksum: 0a703d871bf062c5fdc7850b1496693b (MD5) pham_HHMI_2012_presentation.pdf: 616829 bytes, checksum: c888dc370215c37027577ec1c21141c9 (MD5) pham_HHMI_2012_presentation.pptx: 894039 bytes, checksum: c00cb552cf0158970c5ab43441e45e6c (MD5)
  • description.provenance : Submitted by Tuan Pham (phamtuan@onid.orst.edu) on 2013-06-07T18:09:00Z No. of bitstreams: 3 license_rdf: 1232 bytes, checksum: bb87e2fb4674c76d0d2e9ed07fbb9c86 (MD5) pham_HHMI_2012_presentation.pdf: 616829 bytes, checksum: c888dc370215c37027577ec1c21141c9 (MD5) pham_HHMI_2012_presentation.pptx: 894039 bytes, checksum: c00cb552cf0158970c5ab43441e45e6c (MD5)

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