A Computational Fluid Dynamics Investigation of Hemolysis Potential in a Microfluidic Hemoperfusion Device Designed for Use in Sepsis Treatment Public

http://ir.library.oregonstate.edu/concern/honors_college_theses/v979v488q

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  • The potential of red blood cell (RBC) and platelet damage was studied for a novel microfluidic hemoperfusion device currently in development at Oregon State University for use in treating sepsis. COMSOL 4.4's computational fluid dynamics (CFD) module was used to examine shear rate profiles in laminar, Newtonian blood flow throughout pre-specified lamina dimensions. The shear rates observed were converted into blood damage statistics using the average residence time and equations that estimates (1) total fraction of hemolysis and (2) critical shear stress at which hemolysis begins to take place. The resulting hemolysis values for the current flow rate (0.3mL/min) and a hematocrit of 45% were 0.0148% of RBCs and 0.00122% of platelets. For 65% hematocrit, hemolysis values increased to 0.0511% for RBCs and 0.00591% for platelets. In terms of the critical threshold for hemolysis to start occurring, in 45% hematocrit flow, shear stresses applied to RBCs reached only 6.65% of the critical threshold for hemolysis; platelets reached 11.4% of that threshold. At 65% hematocrit, RBCs and platelets reached 11.1% and 18.9% of the critical threshold respectively. Thus, it can be initially concluded that the mechanical stresses in the current lamina design do not produce significant levels of blood hemolysis.
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