Independent Association of Vitamin D with Prevalent and Incident Outcomes of Heart Attack and Stroke in Elderly Men: A Prospective Cohort Study Public

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  • BACKGROUND: The association of vitamin D with heart attack and stroke remains unclear. METHOD: Using data from the Osteoporotic Fractures in Men Study (MrOS), we collected dietary vitamin D data from 5,995 participants and serum (25)OH vitamin D from 1,606 participants. The association of vitamin D with prevalent heart attack and strokes was studied using an unconditional logistic regression model. Then, incidence of heart attack and stroke was prospectively studied using a log binomial model. RESULTS: In the analysis of prevalence, a non-significant inverse relationship between vitamin D and heart attack and stroke was observed. However, participants in the highest quartile of dietary vitamin D reported significantly fewer prevalent strokes than men in the lowest quartile (prevalence ratio, 0.72; p=0.04). In the incidence analysis, the data was largely inconclusive. In the dietary vitamin D analyses, the highest quartile dietary vitamin D was generally associated with a non-significant decreased odds of heart attack (odds ratio, 0.98; p=0.91) and stroke (odds ratio 0.97; p=0.98). Similarly, in the serum analysis, the highest quartile of serum vitamin was associated with a non-significant decreased odds of heart attack (odds ratio, 0.82; p=0.49) and stroke (odds ratio 0.57; p=0.10). CONCLUSION: Vitamin D was not significantly protective against incidents of heart attack and stroke. While the majority of our results showed a minor protective effect, it was too small to make definitive conclusions.
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  • description.provenance : Submitted by Heather Boren (heather.boren@oregonstate.edu) on 2009-07-28T18:51:38ZNo. of bitstreams: 1Messenger.pdf: 269708 bytes, checksum: f932b520435adbd7f164ab6a8e22ddfb (MD5)
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