Honors College Thesis

 

Independent Association of Vitamin D with Prevalent and Incident Outcomes of Heart Attack and Stroke in Elderly Men: A Prospective Cohort Study Public Deposited

Contenu téléchargeable

Télécharger le fichier PDF
https://ir.library.oregonstate.edu/concern/honors_college_theses/vx021g83t

Descriptions

Attribute NameValues
Creator
Abstract
  • BACKGROUND: The association of vitamin D with heart attack and stroke remains unclear. METHOD: Using data from the Osteoporotic Fractures in Men Study (MrOS), we collected dietary vitamin D data from 5,995 participants and serum (25)OH vitamin D from 1,606 participants. The association of vitamin D with prevalent heart attack and strokes was studied using an unconditional logistic regression model. Then, incidence of heart attack and stroke was prospectively studied using a log binomial model. RESULTS: In the analysis of prevalence, a non-significant inverse relationship between vitamin D and heart attack and stroke was observed. However, participants in the highest quartile of dietary vitamin D reported significantly fewer prevalent strokes than men in the lowest quartile (prevalence ratio, 0.72; p=0.04). In the incidence analysis, the data was largely inconclusive. In the dietary vitamin D analyses, the highest quartile dietary vitamin D was generally associated with a non-significant decreased odds of heart attack (odds ratio, 0.98; p=0.91) and stroke (odds ratio 0.97; p=0.98). Similarly, in the serum analysis, the highest quartile of serum vitamin was associated with a non-significant decreased odds of heart attack (odds ratio, 0.82; p=0.49) and stroke (odds ratio 0.57; p=0.10). CONCLUSION: Vitamin D was not significantly protective against incidents of heart attack and stroke. While the majority of our results showed a minor protective effect, it was too small to make definitive conclusions.
License
Resource Type
Date Available
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Non-Academic Affiliation
Déclaration de droits
Publisher
Peer Reviewed
Language
Replaces

Des relations

Parents:

This work has no parents.

Dans Collection:

Articles