Honors College Thesis
 

Effects of Estrogen Receptor Blockade on Skeletal Response to Alcohol in Ovariectomized Rats

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https://ir.library.oregonstate.edu/concern/honors_college_theses/vx021g843

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  • Heavy alcohol consumption reduces peak bone mass in growing rodents and can lead to bone loss in both adult rats and humans. In contrast, moderate alcohol consumption appears to have a bone sparing effect in post-menopausal women. Alcohol has been reported to increase aromatase activity and influence estrogen receptor (ER) number and signaling in rats. Thus, both the putative protective and detrimental effects of alcohol on the skeleton may be mediated through altered estrogen signaling. We determined whether blocking estrogen receptor signaling using ICI 182,780 (ICI), a potent estrogen receptor antagonist, influences the skeletal response to heavy alcohol consumption in ovariectomized (ovx) rats with established bone loss. Three weeks following ovariectomy, rats were divided into five groups: 1) baseline, 2) control + vehicle, 3) control + ICI, 4) alcohol + VEH, 5) alcohol + ICI and were treated accordingly for 4 weeks. Tibiae were evaluated by dual energy X-ray absorptiometry (DXA) and micro-computed tomography (μCT). Alcohol consumption decreased weight gain and bone mass accrual but increased percent body fat. Bone microarchitecture of the tibia was also altered by alcohol consumption. Specifically, there was a reduction in the overall accrual of cortical bone and net loss of cancellous bone. Co-treatment with ICI had no independent effects and did not alter the skeletal response to alcohol. In conclusion, alcohol resulted in cancellous and cortical osteopenia but we found no evidence in ovx rats to support the hypothesis that changes in ER signaling mediate the detrimental skeletal actions of alcohol.
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