Characterization of CTIP1 interaction with HP1 Public Deposited

http://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/x920g229j

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • COUP-TF interacting protein 1 (CTIP1) is a novel C2H2 zinc finger protein that mediates transcriptional repression of ARP1, a member of the COUP-TF subfamily of orphan nuclear receptors [1]. Here we show that CTIP1 interacts with heterochromatin-associated protein 1 (HP1) in vitro and in cells. This interaction suggests the existence of a novel mechanism of transcriptional repression for COUP-TFs, which may involve association with heterochromatin. Analysis of in vitro interaction of different CTIPI deletion mutants with HP1 reveals that the amino terminal region of CTIP1 as well as the central core interact with HP1. These two domains were previously shown to mediate transcriptional repression when fused to GAL4 DBD [1] suggesting that association with HP1 proteins may be implicated in the repression function.
Resource Type
Date Available
Date Issued
Degree Level
Degree Name
Degree Grantor
Advisor
Committee Member
Non-Academic Affiliation
Rights Statement
Language
File Format
File Extent
  • 667919 bytes
Digitization Specifications
  • Master files scanned at 600 ppi (256 Grayscale) using Capture Perfect 3.0 on a Canon DR-9080C in TIF format. PDF derivative scanned at 300 ppi (256 B+W and 256 grayscale), using Capture Perfect 3.0, on a Canon DR-9080C. CVista PdfCompressor 3.1 was used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Made available in DSpace on 2007-12-11T17:46:21Z (GMT). No. of bitstreams: 1 Huddlest.pdf: 667919 bytes, checksum: 6f6e7004a8cdeafb0417afaf358df077 (MD5)
  • description.provenance : Submitted by Sara MIntonye (smscanner@gmail.com) on 2007-12-10T22:12:13Z No. of bitstreams: 1 Huddlest.pdf: 667919 bytes, checksum: 6f6e7004a8cdeafb0417afaf358df077 (MD5)
  • description.provenance : Approved for entry into archive by Linda Kathman(linda.kathman@oregonstate.edu) on 2007-12-11T17:46:21Z (GMT) No. of bitstreams: 1 Huddlest.pdf: 667919 bytes, checksum: 6f6e7004a8cdeafb0417afaf358df077 (MD5)

Relationships

In Administrative Set:
Last modified: 10/27/2017

Downloadable Content

Download PDF
Citations:

EndNote | Zotero | Mendeley

Items