Evaluation of Bacterial F1FO-ATPase Inhibitors for Synergistic Effects Public Deposited

http://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/xd07gv85m

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  • F1FO-ATP synthase targeting antimicrobials apoptolidin 1 (A1), (+)-erythromefloquine, and oligomycin were tested in vitro for synergistic minimum inhibitory concentrations against Staphylococcus aureus. Synergy was strictly defined as inhibition by at most 25% the MIC of each participating drug. Ampicillin, with an MIC of 0.8 ug/mL, served as a negative control. (+)-erythro-Mefloquine displayed an MIC of 12.5 ug/mL, while oligomycin had an MIC of 1.25 mg/mL. Apoptolidin A1 consistently hindered, yet never completely inhibited, the growth of S. aureus. In combination, (+)- erythro-mefloquine and apoptolidin A1 yielded an indifferent result. Oligomycin with (+)-erythro-mefloquine displayed an antagonistic relationship. One trial of (+)-erythromefloquine with ampicillin suggested an additive relationship might be present.
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  • description.provenance : Made available in DSpace on 2011-12-12T23:22:36Z (GMT). No. of bitstreams: 1 Thesis Final.pdf: 2893084 bytes, checksum: 0befcc0b1bf6aa6ddbd727cd0ea48d14 (MD5)
  • description.provenance : Submitted by Heather Boren (heather.boren@oregonstate.edu) on 2011-12-12T23:22:36Z No. of bitstreams: 1 Thesis Final.pdf: 2893084 bytes, checksum: 0befcc0b1bf6aa6ddbd727cd0ea48d14 (MD5)

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