Evaluation of Bacterial F1FO-ATPase Inhibitors for Synergistic Effects

Honors College Thesis

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Citeable URL: https://ir.library.oregonstate.edu/concern/honors_college_theses/xd07gv85m

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Attribute Name	Values
Creator	Heppe, Kenan G.
Abstract	F1FO-ATP synthase targeting antimicrobials apoptolidin 1 (A1), (+)-erythromefloquine, and oligomycin were tested in vitro for synergistic minimum inhibitory concentrations against Staphylococcus aureus. Synergy was strictly defined as inhibition by at most 25% the MIC of each participating drug. Ampicillin, with an MIC of 0.8 ug/mL, served as a negative control. (+)-erythro-Mefloquine displayed an MIC of 12.5 ug/mL, while oligomycin had an MIC of 1.25 mg/mL. Apoptolidin A1 consistently hindered, yet never completely inhibited, the growth of S. aureus. In combination, (+)- erythro-mefloquine and apoptolidin A1 yielded an indifferent result. Oligomycin with (+)-erythro-mefloquine displayed an antagonistic relationship. One trial of (+)-erythromefloquine with ampicillin suggested an additive relationship might be present.
License	All rights reserved
Resource Type	Honors College Thesis
Date Available	2011-12-12T23:22:36+00:00
Date Issued	2011-05-26
Degree Level	Bachelor's
Degree Name	Honors Bachelor of Science (H.B.S.)
Degree Field	Chemistry
Degree Grantor	Oregon State University
Commencement Year	2011
Advisor	Zabriskie, T. Mark
Committee Member	Firpo, Emile Blakemore, Paul
Non-Academic Affiliation	Oregon State University. Honors College
Rights Statement	In Copyright
Publisher	Oregon State University
Peer Reviewed	No
Language	English [eng]
Replaces	http://hdl.handle.net/1957/26015

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