Honors College Thesis
 

Exploring reproductive signaling using nonconventional aquatic models : Aging and reproductive function in killifish and sea anemones

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https://ir.library.oregonstate.edu/concern/honors_college_theses/xg94hr66m

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  • Aquatic animals possess surprising similarities to humans in reproductive signaling that are simplified or elaborated for life underwater, making them useful for studying reproductive control. In this thesis, killifish and sea anemones are used as models for reproductive function and aging. The aging model Nothobranchius (killifish) was used to investigate circadian rhythms and clock gene expression in reproductive tissues, and effects of the anti-aging compound resveratrol (RSV) were examined to elucidate the role of clock genes in fertility. Weak connections were found between gonadal clock gene expression and age, and RSV altered expression over time and shifted rhythmic patterns in old fish, suggesting that it may modulate circadian rhythms with age. Additionally, to understand the physiological mechanisms behind coral spawning for conservation and elucidate hormonal evolution, functions of the cnidarian leucine-rich repeat-containing G protein-coupled receptor LGRA2 were investigated in the model sea anemone Aiptasia pallida. LGRA2 was expressed near gonadal regions of sexually developed sea anemones, activated by gonadotropins, and modulated by estrogen, indicating that it is involved in regulating reproduction similarly to its mammalian homologs luteinizing hormone receptor and follicle stimulating hormone receptor. These projects together provide a One Health view of reproductive signaling and aging. Key Words: reproductive endocrinology, circadian rhythms, aging, gonadotropin signaling, coral reproduction
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  • OSU Honors Experience Award, OSU College of Science Summer Undergraduate Research Experience
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file details Honors_Thesis_2017_final.pdf 2017-07-30 Público Descargar