Resistance to Schistosoma mansoni is correlated with the number of spreading granulocytes in Biomphalaria glabrata Public Deposited

http://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/xw42n938g

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  • Molluscan internal defenses rely heavily on circulating hemocytes. In most cases, encounters with large foreign bodies result in recognition by hemocytes followed by spreading of these defense cells over the object’s surface. The resulting encapsulation concentrates the force of the hemocytes’ assault on the foreign object. B. glabrata snail lines obtained by self-fertilization of isolated 13-16-R1 [Oregon] individuals have yielded multiple inbred families in which genes are fixed at ~88% of the loci. Among the phenotypic traits that we have measured in 20 of these families are susceptibilities of snails to the PR1 [Oregon] strain of Schistosoma mansoni, and hematocrits of quickly spreading granulocytes present in the hemolymph.  Higher numbers of these cells predict a snail phenotype that is resistant to S. mansoni infection. Both resistant and susceptible snails are found in families with intermediate hematocrits. We infer that within the parental 13-16-R1 population hemocyte numbers are varied. When sufficiently numerous, a snail’s hemocytes can generally prevent parasitic infection. At lower hematocrits, a more complex set of variables interact to determine the outcome of an infection.
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