DNA methylation is a well-recognized epigenetic mechanism that has been the subject of a growing
body of literature typically focused on the identification and study of profiles of DNA methylation and their
association with human diseases and exposures. In recent years, a number of unsupervised clustering algorithms,
both parametric and...
Elevated hepatic expression of fatty acid elongase-5 (Elovl5) induces
FoxO1 phosphorylation, lowers FoxO1 nuclear content and suppresses expression of
genes involved in gluconeogenesis. In this report we define the molecular and metabolic
basis of Elovl5 control of FoxO1 phosphorylation. Adenoviral-mediated (Ad-Elovl5)
induction of hepatic Elovl5 in diet induced obese-glucose intolerant...
Objective: Millions of US households experienced food insecurity in 2005.
Research indicates that low wages and little social support contribute to food
insecurity. The present study aimed to examine whether social support moderates
the relationship between income and food insecurity.
Design: Using a mail survey, we collected data on social...
Objective: This study examines obstetrician/gynecologists and family medicine physicians' reported care patterns, attitudes and beliefs and predictors of adherence to postpartum testing in women with a history of gestational diabetes mellitus.
Research Design and Methods: In November-December 2005, a mailed survey went to a random, cross-sectional sample of 683 Oregon...
During explosive movements and potentially injurious situations the ability to rapidly generate torque is critical. Previous research has suggested different phases of rate of torque development (RTD) are differentiately controlled. However, the extent to which supraspinal and spinal mechanisms predict RTD at different time intervals is unknown. RTD of the...
Background:
The people of Bangladesh are currently exposed to high concentrations of arsenic and manganese in drinking water, as well as elevated lead in many regions. The objective of this study was to investigate associations between environmental exposure to these contaminants and neurodevelopmental outcomes among Bangladeshi children.
Methods:
We evaluated...
Background: There is increasing epidemiologic evidence that arsenic exposure in utero, even at low levels found throughout much of the world, is associated with adverse reproductive outcomes and may contribute to long-term health effects. Animal models, in vitro studies, and human cancer data suggest that arsenic may induce epigenetic alterations,...
Health officials have recently been sounding the alarm that depression will soon
surpass many of the major medical conditions in causing disability among adults. Recent
demographic and health trends are generating public health concern about depression.
First, the prevalence of chronic conditions has dramatically increased over the last several
generations....
West Nile Virus (WNV), a vector-borne disease continues to be a serious threat to public health in the United States, particularly in the Southwest region. While all the states in the U.S. experienced a decreasing trend of WNV disease in 2010, the state of Arizona experienced a sharp increase from...
Two epidemiological studies, designed to expand our knowledge of morbidity and
mortality indicators concerning malaria and Bacillus Calmette-Guerin vaccination in the
Hospital Albert Schweitzer health district located in Central Haiti's Artibonite Valley, are
presented. The hospital serves a rural population of 190,000 in its 610 square mile
district. A large...