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Identification and Characterization of Human Cytomegalovirus-Encoded MicroRNAs

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https://ir.library.oregonstate.edu/concern/articles/df65v863v

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  • MicroRNAs (miRNAs) are an extensive class of noncoding genes that regulate gene expression through posttranscriptional repression. Given the potential for large viral genomes to encode these transcripts, we examined the human cytomegalovirus AD169 genome for miRNAs using a bioinformatics approach. We identified 406 potential stem-loops, of which 110 were conserved between chimpanzee cytomegalovirus and several strains of human cytomegalovirus. Of these conserved stem-loops, 13 exhibited a significant score using the MiRscan algorithm. Examination of total RNA from human cytomegalovirus-infected cells demonstrated that 5 of the 13 predicted miRNAs were expressed during infection. These studies demonstrate that human cytomegalovirus encodes multiple conserved miRNAs and suggest that human cytomegalovirus may utilize an miRNA strategy to regulate cellular and viral gene function
  • Originally published in Journal of Virology (http://jvi.asm.org/) by American Society for Microbiology
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  • Grey, F., Antoniewicz, A., Allen, E., Saugstad, J., McShea, A., Carrington, J. C., & Nelson, J. (2005). Identification and Characterization of Human Cytomegalovirus-Encoded MicroRNAs. Journal of Virology, 79(18), 12095-12099
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  • 79
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  • This work was supported by a Public Health Service grant from the National Institutes of Health (AI21640 to J.A.N.) and by a National Science Foundation grant (MCB-0209836 to J.C.C.).
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