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Label free biosensing with carbon nanotube transistors

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dc.contributor.advisor Minot, Ethan
dc.creator Leyden, Matthew R.
dc.date.accessioned 2011-06-10T18:01:28Z
dc.date.available 2011-06-10T18:01:28Z
dc.date.copyright 2011-05-20
dc.date.issued 2011-06-10
dc.identifier.uri http://hdl.handle.net/1957/21717
dc.description Graduation date: 2011 en_US
dc.description.abstract As electronics reach nanometer size scales, new avenues of integrating biology and electronics become available. For example, nanoscale field-effect transistors have been integrated with single neurons to detect neural activity. Researchers have also used nanoscale materials to build electronic ears and noses. Another exciting development is the use of nanoscale biosensors for the point-of-care detection of disease biomarkers. This thesis addresses many issues that are relevant for electrical sensing applications in biological environments. As an experimental platform we have used carbon nanotube field-effect transistors for the detection of biological proteins. Using this experimental platform we have probed many of properties that control sensor function, such as surface potentials, the response of field effect transistors to absorbed material, and the mass transport of proteins. Field effect transistor biosensors are a topic of active research, and were first demonstrated in 1962. Despite decades of research, the mass transport of proteins onto a sensor surface has not been quantified experimentally, and theoretical modeling has not been reconciled with some notable experiments. Protein transport is an important issue because signals from low analyte concentrations can take hours to develop. Guided by mass transport modeling we modified our sensors to demonstrate a 2.5 fold improvement in sensor response time. It is easy to imagine a 25 fold improvement in sensor response time using more advanced existing fabrication techniques. This improvement would allow for the detection of low concentrations of analyte on the order of minutes instead of hours, and will open the door point-of-care biosensors. en_US
dc.language.iso en_US en_US
dc.relation Biodiversity Portal en_US
dc.subject Biosensor en_US
dc.subject Microfluidics en_US
dc.subject Carbon nanotube en_US
dc.subject Field effect transistor en_US
dc.title Label free biosensing with carbon nanotube transistors en_US
dc.type Thesis/Dissertation en_US
dc.degree.name Doctor of Philosophy (Ph. D.) in Physics en_US
dc.degree.level Doctoral en_US
dc.degree.discipline Science en_US
dc.degree.grantor Oregon State University en_US
dc.contributor.committeemember Koretsky, Milo
dc.contributor.committeemember Ostroverkhova, Oksana
dc.contributor.committeemember Conley, John F. Jr
dc.contributor.committeemember Schneider, Guenter

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