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Interplay between HIV-1 infection and host microRNAs

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dc.creator Sun, Guihua
dc.creator Li, Haitang
dc.creator Wu, Xiwei
dc.creator Covarrubias, Maricela
dc.creator Scherer, Lisa
dc.creator Meinking, Keith
dc.creator Luk, Brian
dc.creator Chomchan, Pritsana
dc.creator Alluin, Jessica
dc.creator Gombart, Adrian F.
dc.creator Rossi, John J.
dc.date.accessioned 2012-07-23T20:31:41Z
dc.date.available 2012-07-23T20:31:41Z
dc.date.issued 2012-03
dc.identifier.citation Sun, G., Li, H., Wu, X., Covarrubias, M., Scherer, L., Meinking, K., . . . . (2012). Interplay between HIV-1 infection and host microRNAs. Nucleic Acids Research, 40(5), 2181-2196. doi: 10.1093/nar/gkr961 en_US
dc.identifier.uri http://hdl.handle.net/1957/31443
dc.description This is the publisher’s final pdf. The published article is copyrighted by Oxford University Press and can be found at: http://global.oup.com/?cc=us. en_US
dc.description.abstract Using microRNA array analyses of in vitro HIV-1-infected CD4(+) cells, we find that several host microRNAs are significantly up- or downregulated around the time HIV-1 infection peaks in vitro. While microRNA-223 levels were significantly enriched in HIV-1-infected CD4(superscript+)CD8(superscript-) PBMCs, microRNA-29a/b, microRNA-155 and microRNA-21 levels were significantly reduced. Based on the potential for microRNA binding sites in a conserved sequence of the Nef-3'-LTR, several host microRNAs potentially could affect HIV-1 gene expression. Among those microRNAs, the microRNA-29 family has seed complementarity in the HIV-1 3'-UTR, but the potential suppressive effect of microRNA-29 on HIV-1 is severely blocked by the secondary structure of the target region. Our data support a possible regulatory circuit at the peak of HIV-1 replication which involves downregulation of microRNA-29, expression of Nef, the apoptosis of host CD4 cells and upregulation of microRNA-223. en_US
dc.language.iso en_US en_US
dc.publisher Oxford University Press en_US
dc.relation.ispartofseries Nucleic Acids Research en_US
dc.relation.ispartofseries Vol. 40 no. 5 en_US
dc.subject Immunodeficiency-virus type-1 en_US
dc.subject NF-[Kappa]-B en_US
dc.subject Chronic lymphocytic-leukemia en_US
dc.subject Inhibitor factor lif en_US
dc.subject CD4(+) T-cells en_US
dc.subject Transcription factors en_US
dc.subject Cellular microRNA en_US
dc.subject RNA interference en_US
dc.subject Site Accessibility en_US
dc.subject Protooncogene TCL1 en_US
dc.title Interplay between HIV-1 infection and host microRNAs en_US
dc.type Article en_US
dc.identifier.doi 10.1093/nar/gkr961

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