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Chromatin structural changes around satellite repeats on the female sex chromosome in Schistosoma mansoni and their possible role in sex chromosome emergence

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dc.creator Lepesant, Julie M. J.
dc.creator Cosseau, Celine
dc.creator Boissier, Jerome
dc.creator Freitag, Michael
dc.creator Portela, Julien
dc.creator Climent, Deborah
dc.creator Perrin, Cecile
dc.creator Zerlotini, Adhemar
dc.creator Grunau, Christoph
dc.date.accessioned 2012-08-23T14:56:29Z
dc.date.available 2012-08-23T14:56:29Z
dc.date.issued 2012-02-29
dc.identifier.citation Lepesant, J., Cosseau, C., Boissier, J., Freitag, M., Portela, J., Climent, D., . . . . (2012). Chromatin structural changes around satellite repeats on the female sex chromosome in schistosoma mansoni and their possible role in sex chromosome emergence. Genome Biology, 13(2) doi: 10.1186/gb-2012-13-2-r14 en_US
dc.identifier.uri http://hdl.handle.net/1957/32817
dc.description This is the publisher’s final pdf. The published article is copyrighted by BioMed Central Ltd. and can be found at: http://www.biomedcentral.com/. en_US
dc.description.abstract Background: In the leuphotrochozoan parasitic platyhelminth Schistosoma mansoni, male individuals are homogametic (ZZ) whereas females are heterogametic (ZW). To elucidate the mechanisms that led to the emergence of sex chromosomes, we compared the genomic sequence and the chromatin structure of male and female individuals. As for many eukaryotes, the lower estimate for the repeat content is 40%, with an unknown proportion of domesticated repeats. We used massive sequencing to de novo assemble all repeats, and identify unambiguously Z-specific, W-specific and pseudoautosomal regions of the S. mansoni sex chromosomes. Results: We show that 70 to 90% of S. mansoni W and Z are pseudoautosomal. No female-specific gene could be identified. Instead, the W-specific region is composed almost entirely of 36 satellite repeat families, of which 33 were previously unknown. Transcription and chromatin status of female-specific repeats are stage-specific: for those repeats that are transcribed, transcription is restricted to the larval stages lacking sexual dimorphism. In contrast, in the sexually dimorphic adult stage of the life cycle, no transcription occurs. In addition, the euchromatic character of histone modifications around the W-specific repeats decreases during the life cycle. Recombination repression occurs in this region even if homologous sequences are present on both the Z and W chromosomes. Conclusion: Our study provides for the first time evidence for the hypothesis that, at least in organisms with a ZW type of sex chromosomes, repeat-induced chromatin structure changes could indeed be the initial event in sex chromosome emergence. en_US
dc.description.sponsorship The work received financial support from the CNRS (PostDoc fellowship to CC) and the programs ‘Schistophepigen’ and ‘Monogamix’ from the French National Agency for Research (ANR). en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central Ltd. en_US
dc.relation.ispartofseries Genome Biology en_US
dc.relation.ispartofseries Vol. 13 no. 2 en_US
dc.subject Repetitive DNA en_US
dc.subject Biophalaria glabrata en_US
dc.subject Argonaute Proteins en_US
dc.subject Separate sexes en_US
dc.subject Y chromosomes en_US
dc.subject Evolution en_US
dc.subject Genome en_US
dc.subject Dicer en_US
dc.subject Heterochromatin en_US
dc.subject Methylation en_US
dc.title Chromatin structural changes around satellite repeats on the female sex chromosome in Schistosoma mansoni and their possible role in sex chromosome emergence en_US
dc.type Article en_US
dc.description.peerreview yes en_US
dc.identifier.doi 10.1186/gb-2012-13-2-r14


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