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TCDD: An Environmental Immunotoxicant Reveals a Novel Pathway of Immunoregulation—A 30-Year Odyssey

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dc.creator Kerkvliet, Nancy I.
dc.date.accessioned 2012-10-16T22:07:18Z
dc.date.available 2013-10-15T22:18:25Z
dc.date.issued 2012-02
dc.identifier.citation Kerkvliet, N. (2012). TCDD: An environmental immunotoxicant reveals a novel pathway of immunoregulation-A 30-year odyssey. TOXICOLOGIC PATHOLOGY, 40(2), 138-142. doi: 10.1177/0192623311427710 en_US
dc.identifier.uri http://hdl.handle.net/1957/34479
dc.description This is the author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Sage Publications Inc. and can be found at: http://tpx.sagepub.com/. en_US
dc.description.abstract I was honored to be the keynote speaker at the 30th Annual Society of Toxicologic Pathology Symposium “Toxicologic Pathology and the Immune System.” I had the opportunity to reminisce about events in the 1970s that set the stage for the birth and subsequent growth of the field of immunotoxicology and to summarize my research career that has spanned the past 40 years as well. An initial focus on the immunotoxicity of pentachlorophenol led my laboratory into the aryl hydrocarbon receptor (AHR) field and the study of its most potent ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). My research career has been devoted to trying to elucidate the immunological basis of TCDD’s profound immunosuppressive activity that is mediated by activation of AHR. In recent years, my laboratory has focused on the role of CD4⁺ T cells as targets of TCDD, and we were the first to describe the induction of AHR-dependent regulatory T cells (Tregs). The ability to induce Tregs using an exogenous AHR ligand to activate the AHR-Treg pathway represents a novel approach to the prevention and/or treatment of autoimmune disease. We are currently searching for such ligands. en_US
dc.language.iso en_US en_US
dc.publisher Sage Publications Inc. en_US
dc.relation.ispartofseries Toxicologic Pathology en_US
dc.relation.ispartofseries Vol. 40 no. 2 en_US
dc.subject immunotoxicology en_US
dc.subject 2,3,7,8-tetrachlorodibenzo-p-dioxin en_US
dc.subject TCDD en_US
dc.subject aryl hydrocarbon receptor en_US
dc.subject AHR en_US
dc.subject CD4⁺ en_US
dc.subject regulatory T cells en_US
dc.title TCDD: An Environmental Immunotoxicant Reveals a Novel Pathway of Immunoregulation—A 30-Year Odyssey en_US
dc.title.alternative Keynote Address: TCDD: An Environmental Immunotoxicant Reveals a Novel Pathway of Immunoregulation - A 30-Year Odyssey en_US
dc.type Article en_US
dc.description.peerreview yes en_US
dc.identifier.doi 10.1177/0192623311427710
dc.description.embargopolicy Repository Administrators en


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