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Examining the Use of Ceftaroline in the Treatment of Streptococcus pneumoniae Meningitis with Reference to Human Cathelicidin LL-37

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  • Five cases of bacterial meningitis treated with ceftaroline (4 Streptococcus pneumoniae and 1 Staphylococcus aureus) are summarized here. The pharmacodynamics of human cathelicidin LL-37 and ceftaroline were evaluated against S. pneumoniae. Patients who received ceftaroline 600 mg every 8 h (q8h) (1 S. aureus and 3 S. pneumoniae) were successfully treated; treatment failed in 1 patient with S. pneumoniae who received 600 mg q12h. Ceftaroline increased the negative surface charge and sensitized S. pneumoniae to killing by LL-37, a peptide implicated in blood-brain barrier defense.
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  • Sakoulas, G., Nonejuie, P., Kullar, R., Pogliano, J., Rybak, M. J., & Nizet, V. (2015). Examining the Use of Ceftaroline in the Treatment of Streptococcus pneumoniae Meningitis with Reference to Human Cathelicidin LL-37. Antimicrobial agents and chemotherapy, 59(4), 2428-2431. doi:10.1128/AAC.04965-14
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  • 59
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  • 4
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  • Funding for this research was provided by U54 HD071600-0109/26/2011-06/30/2016 NICHD on Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy (to G.S. and V.N.).G.S. has received speaking honoraria from Cubist, Forest, and Novartis Pharmaceuticals, consulting fees from Cubist and Forest Pharmaceuticals, and research grant support from Forest Pharmaceuticals. M.J.R. has received speaking honoraria from Cubist, Forest, Novartis, and Sunovion, consulting fees from Durata, Cubist, Forest, Cepheid, and Theravance, and research grant support from Cubist, Forest, and Cerexa Pharmaceuticals.
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