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Filtering by: Advisor Mahmud, Taifo Remove constraint Advisor: Mahmud, Taifo Decade 2010-2019 Remove constraint Decade: 2010-2019

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  • Evolutionary and Biochemical Studies of C₇-cyclitol Synthases and their Sunscreen Gene Clusters

    Creator:
    Osborn, Andrew
    Abstract:
    Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...
    Resource Type:
    Dissertation
    Full Text:
    . Abstract approved: ______________________________________________________ Taifo Mahmud Sugar

  • Exploring the Synthesis of 4-Deoxygadusol

    Creator:
    Jujjuri, Anantha Poojitha
    Abstract:
    Sunscreen products are used worldwide to protect the skin from ultraviolet radiation. However, some of the ingredients used in sunscreen products are fatal to coral reefs especially in areas where tourism is a large part of the economy. In this study, we explored a synthetic route to produce 4-deoxygadusol, which...
    Resource Type:
    Honors College Thesis
    Full Text:
    :_____________________________________________________ Taifo Mahmud Sunscreen products are used worldwide to protect the skin from ultraviolet

  • Exploring Pactamycin Biosynthesis

    Creator:
    Roland, Jessica
    Abstract:
    Pactamycin, produced by the soil bacterium Streptomyces pactum, is a cytotoxic antibiotic that belongs to the aminocyclitol family of natural products. This antibiotic has shown various forms of biological activity, including antibacterial, antifungal, antimalarial, and antitumor activities. Despite its outstanding biological activity, the mode of formation of its pharmacophore (the...
    Resource Type:
    Honors College Thesis
    Full Text:
    :_____________________________________________________ Taifo Mahmud Pactamycin, produced by the soil bacterium Streptomyces pactum, is a

  • Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

    Creator:
    Brumsted, Corey J.
    Abstract:
    Pactamycin, first reported in 1962, is a potent antitumor antibiotic produced by the soil bacterium Streptomyces pactum. Structurally, it contains a cyclopentitol core unit, a 3-aminoacetophenone (3AAP), a 6-methylsalicylic acid (6-MSA), and a N,N-dimethyl urea. The aminocyclopentitol ring is derived from glucose, possibly via N-acetyl glucosamine (GlcNAc), the 3-aminoacetophenone (3AAP)...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Taifo Mahmud Pactamycin, first reported in 1962, is a potent antitumor antibiotic

  • Biosynthesis and Rational Design of Novel Pactamycin Analogs

    Creator:
    Abugrain, Mostafa E.
    Abstract:
    Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomycespactum, is a structurally unique aminocyclopentitol-containing natural product. Itconsists of a highly functionalized cyclopentitol core unit, two aromatic rings [3-aminoacetophenone (3AAP) and 6-methylsalicylic acid (6MSA)], and a 1,1-dimethylurea moiety. Despite its potent biological activity, the development of thisantibiotic was hampered...
    Resource Type:
    Dissertation
    Full Text:
    acknowledge my major advisor, Prof. Taifo Mahmud, for his guidance and support. He has encouraged me when

  • Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

    Creator:
    Sheng, Yan
    Abstract:
    The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically...
    Resource Type:
    Dissertation
    Full Text:
    . Abstract approved: _____________________________________________________________________ Taifo Mahmud

  • Multiple Approaches to Novel Rifamycin Analogs to Combat MDR-TB

    Creator:
    Blank, Jessica A.
    Abstract:
    According to the Center for Disease Control and Prevention (CDC), in 2015 10.4 million people worldwide became infected with tuberculosis (TB) with 1.8 million TB related deaths. Tuberculosis is a bacterial infectious disease caused by Mycobacterium tuberculosis, a slow growing yet highly infectious bacterium. Among the first line of treatments...
    Resource Type:
    Honors College Thesis
    Full Text:
    : ________________________________________________________________________ Taifo Mahmud According to the Center for Disease Control and Prevention (CDC), in 2015

  • Development of Novel Agents to Combat Tuberculosis and Malaria

    Creator:
    Almabruk, Khaled Husain G.
    Abstract:
    Despite the advance of biomedical science, infectious diseases remain one of the number one killers in the world. They claim the lives of millions of people annually, particularly in underdeveloped and developing countries. In fact, more than 32% of the health burden in Africa is caused by infectious diseases, e.g.,...
    Resource Type:
    Dissertation
    Full Text:
    Taifo Mahmud Abstract Despite the advance of biomedical science, infectious diseases remain

  • Antibiotic Discovery in Soil Bacteria Isolated from Indonesian Black Water Ecosystems

    Creator:
    Lam, Phillip Westly
    Abstract:
    Soil bacteria are known to be a prolific source of bioactive compounds. They produce secondary metabolites that can be used as therapeutic agents. This investigation focused on the chemistry and biology of secondary metabolites from two soil bacteria, Streptomyces herbaricolor ICBB 9409 and Streptomyces albiflaviniger ICBB 9297, which were isolated...
    Resource Type:
    Honors College Thesis
    Full Text:
    : __________________________________________________________ Taifo Mahmud Soil bacteria are known to be a prolific source of bioactive compounds

  • Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

    Creator:
    Abuelizz, Hatem A.
    Abstract:
    This thesis describes an investigation of the molecular basis of the substrate specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a newly discovered group of glycosyltransferase (GT)-like proteins that catalyze the transfer of a pseudosugar to an acceptor molecule via a C-N bond formation. This...
    Resource Type:
    Dissertation
    Full Text:
    : _____________________________________________ Taifo Mahmud This thesis describes an investigation of the molecular basis of the substrate