Article
 

Peroxiredoxins: Guardians Against Oxidative Stress and Modulators of Peroxide Signaling

Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/articles/3x816s117

Descriptions

Attribute NameValues
Creator
Abstract
  • Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes that play dominant roles in regulating peroxide levels within cells. These enzymes, often present at high levels and capable of rapidly clearing peroxides, display a remarkable array of variations in their oligomeric states and susceptibility to regulation by hyperoxidative inactivation and other post-translational modifications. Key conserved residues within the active site promote catalysis by stabilizing the transition state required for transferring the terminal oxygen of hydroperoxides to the active site (peroxidatic) cysteine residue. Extensive investigations continue to expand our understanding of the scope of their importance as well as the structures and forces at play within these critical defense and regulatory enzymes.
  • Keywords: redox signaling, peroxidase, antioxidant enzyme, antioxidant defense
Resource Type
DOI
Date Available
Date Issued
Citation
  • Perkins, A., Nelson, K. J., Parsonage, D., Poole, L. B., & Karplus, P. A. (2015). Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling. Trends in Biochemical Sciences, 40(8), 435-445. doi:10.1016/j.tibs.2015.05.001
Journal Title
Journal Volume
  • 40
Journal Issue/Number
  • 8
Rights Statement
Funding Statement (additional comments about funding)
  • Support from the National Institutes of Health (R01 GM050389 to L.B.P. and P.A.K. and R33 CA177461 to L.B.P. and C.M. Furdui) is gratefully acknowledged.
Publisher
Peer Reviewed
Language
Replaces

Relationships

Parents:

This work has no parents.

Items

Thumbnail Title Date Uploaded Visibility Actions
file details KarplusPAndrewBiochemistryBiophysicsPeroxiredoxinsGuardiansAgainstOxidativeStress.pdf 2017-11-01 Public Download