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Quasi-Optical Terahertz Microfluidic Devices for Chemical Sensing and Imaging

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https://ir.library.oregonstate.edu/concern/articles/xd07gv79g

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  • We first review the development of a frequency domain quasi-optical terahertz (THz) chemical sensing and imaging platform consisting of a quartz-based microfluidic subsystem in our previous work. We then report the application of this platform to sensing and characterizing of several selected liquid chemical samples from 570–630 GHz. THz sensing of chemical mixtures including isopropylalcohol-water (IPA-H₂O) mixtures and acetonitrile-water (ACN-H₂O) mixtures have been successfully demonstrated and the results have shown completely different hydrogen bond dynamics detected in different mixture systems. In addition, the developed platform has been applied to study molecule diffusion at the interface between adjacent liquids in the multi-stream laminar flow inside the microfluidic subsystem. The reported THz microfluidic platform promises real-time and label-free chemical/biological sensing and imaging with extremely broad bandwidth, high spectral resolution, and high spatial resolution.
  • Keywords: laminar flow, terahertz, chemical sensing and imaging, molecule diffusion, frequency domain, microfluidic, quasi-optical, label free
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  • Liu, L., Jiang, Z., Rahman, S., Shams, M. I. B., Jing, B., Kannegulla, A., & Cheng, L. (2016). Quasi-Optical Terahertz Microfluidic Devices for Chemical Sensing and Imaging. Micromachines, 7(5), 75. doi:10.3390/mi7050075
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  • 7
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  • 5
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  • The authors acknowledge partial supports from National Science Foundation (NSF) grants ECCS-1002088, ECCS-1102214 and ECCS-1508057, the Advanced Diagnostics and Therapeutics (AD&T) and the Center for Nano Science and Technology (NDnano) at the University of Notre Dame.
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