Graduate Thesis Or Dissertation
 

Anti-obesity and Metabolic Health Impact of Pacific Dulse (Devaleraea mollis) and Nori (Pyropia spp.) Seaweeds in Western Diet-Induced Obese C57BL/6J Mice

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/b8515x47w

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  • Seaweeds have gained tremendous recognition as a highly nutritious and sustainable crop. The diverse components of seaweeds are known to exhibit a wide range of bioactivities, including anti-inflammatory, anti-diabetic, and cardiovascular health benefits. One such promising seaweed is Pacific dulse (Devaleraea mollis). While it holds great cultivating potential on the Oregon Coast, its bioactive health benefits remain largely unexplored. In comparison, nori (Pyropia spp.) is one of the most widely consumed seaweeds worldwide with extensive research knowledge. In this study, we aimed to evaluate the metabolic health impact of dietary supplementation of whole Pacific dulse and nori in diet-induced obesity mice. Fifty C57BL/6J mice were assigned to four experimental groups (n = 12-13), respectively fed a low-fat diet (LFD), Western diet with 41% kcal fat, high sucrose and added cholesterol (WD), WD + 5% nori (WD+N), and WD + 5% dulse (WD+D) for 12 weeks. Supplementation with Pacific dulse significantly suppressed weight gain and food efficiency. Fasting hyperglycemia was suppressed in the WD+D group after 8 weeks, and glucose spikes were significantly delayed up to 15 minutes during IPGTT. Dulse supplementation alleviated hepatic steatosis markers. Notably, the WD+D group retained normal liver characteristics comparable to the LFD control group, including significantly lowered weight and triglyceride level compared to the WD group. The reduction in liver fat accumulation in the WD+D group was confirmed by histological observations. Serum analysis showed a significant reduction by dulse in MCP-1 and leptin levels. In contrast, nori supplementation did not significantly impact any of the above markers. The improvement in hepatic steatosis markers indicates that regulating hepatic lipid metabolism may be a key mechanism of action for Pacific dulse. Moreover, systemic low-grade inflammation was alleviated by Pacific dulse. These results underscore Pacific dulse's potential as a functional food, surpassing the better-known nori in the areas investigated.
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