Graduate Thesis Or Dissertation
 

Insights into Cytostatic and Cytotoxic Properties of the Natural Product Mensacarcin

Öffentlich Deposited

Herunterladbarer Inhalt

PDF Herunterladen
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/qj72pd90x

Descriptions

Attribute NameValues
Creator
Abstract
  • Mensacarcin is a stereogenic complex polyketide with potent anti-tumor activity produced by a soil-dwelling Streptomyces bottropensis. The US National Cancer Institute (NCI) 60 human tumor cell line anticancer drug screen (NCI-60) reveals mensacarcin’s cytostatic properties in almost all tested cell lines and distinct cytotoxic properties specifically in eight melanoma cell lines with an average IC50 value of 0.5-1 μM. We show that mensacarcin activates caspase-3/7-dependent apoptotic pathways and induces apoptosis in melanoma cells and not colon cancer carcinoma cells. Mensacarcin co-localizes in mitochondria and impairs mitochondrial function by either inhibiting mitochondria respiration directly or by causing general mitochondrial dysfunction. Combination of mensacarcin and the standard chemotherapeutic regime for BRAF-mutant melanoma, vemurafenib/zelboraf®, increases efficacy and cytotoxicity synergistically.
License
Resource Type
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Committee Member
Academic Affiliation
Urheberrechts-Erklärung
Publisher
Peer Reviewed
Language
Embargo reason
  • Ongoing Research
Embargo date range
  • 2019-02-21 to 2020-03-21

Beziehungen

Parents:

This work has no parents.

In Collection:

Artikel

Miniaturansicht Titel Hochladedatum Sichtbarkeit Aktionen
file details KaweesaElizabethN2019.pdf 2019-02-20 Öffentlich Herunterladen