Honors College Thesis
 

Regulation of the Metabolic Reprogramming of Schwannoma Cells by Nitrated Hsp90

Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/honors_college_theses/z316q818t

Descriptions

Attribute NameValues
Creator
Abstract
  • This work is concerned with determining whether nicotine has a role in promoting oxidative damage in human tissue, particularly in lung tissue. This follows from recent reports of a novel lung disease found in some E-cigarette users, characterized by oxidative damage and elevated levels of neutrophils (termed “vaping disease”). It is thought that taurine has a protective function against oxidative and chlorinating damage by neutrophil generated hypochlorous acid (HOCl) through the formation of taurine chloramine, a less reactive species. Due to the high concentration of taurine in the lungs, it has been hypothesized that taurine chloramine acts as a “reservoir” for chlorinating potential, as to protect tissue. Our exploratory results have shown that nicotine, a molecule containing a tertiary amino group, is able to catalyze chlorinating reactions of taurine chloramine through the formation of a reactive intermediate, which we suspect to be the nicotine chlorammonium ion. This intermediate exhibits a rapid decline in oxidizing capacity over time, suggesting it degrades autocatalytically after formation. Additionally, we have experimentally demonstrated that this intermediate is able to kill E. coli at physiologically relevant nicotine concentrations. These preliminary results suggest that nicotine may have the ability to catalyze reactions that ultimately cause oxidative damage. Key Words: nicotine, chloramine, chlorammonium ion, taurine, oxidative damage
Resource Type
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Non-Academic Affiliation
Rights Statement
Publisher
Peer Reviewed
Language
Embargo reason
  • Ongoing Research
Embargo date range
  • 2020-06-04 to 2022-07-05

Relationships

Parents:

This work has no parents.

In Collection:

Items

Thumbnail Title Date Uploaded Visibility Actions
file details BastianLydiaP2020.pdf 2020-06-04 Public Download