Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
In the last two decades, there has been an increase in substantial body of work on the inclusion of women in the water management and governance field. However, these scholarly inquiries have mostly focused on cases from the Global South, where women are still underrepresented in decision-making positions in the...
Minimal research has focused on the social dimension of sustainability in the built environment especially as it relates to the construction workforce. As a result, there are few to no tools available to industry stakeholders to holistically assess and improve the social sustainability of the construction workforce. Given the high...
This thesis describes in-vitro and in-vivo evaluation of a transdermal atenolol formulation developed at Oregon State University, College of Pharmacy. The formulation was prepared from carbomer as a gel base with propylene glycol, glycerol, ethanol, polysorbate 80 and dimethyl-isosorbide (DMI) as mixture of penetration enhancing agents. The effect of the...
This presentation, the lead paper at the Libraries, Information Scientists and Cybernetics in a Knowledge Economy Conference, Abeokuta, Nigeria, provides an overview of recent changes in metadata creation. Topics covered include Resource Description and Access after the 3R Project, the Resource Description Framework, BIBFRAME, the Library Reference Model, and Linked...
Catalogers can create subject headings on topics related to the U.N. Sustainable Development Goals. This presentation, given at the Federal University of Agriculture, Abeokuta, focuses on two examples: preparing subject heading proposals for indigenous peoples of Oregon and for crops which are nutrient dense and economically sustainable.
As one of database types, CSV type database is widely used by many people because the type serves various useful purposes for business, engineering, and environment. However, the CSV type database could be complicated to understand because it is usually written on spreadsheet like Microsoft Excel format. Therefore, data visualization...
Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...