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Filtering by: Degree Field Molecular and Cellular Biology Academic Affiliation Animal Sciences Peer Reviewed No

Regulation of skeletal muscle protein degradation by u-calpain and development of a skeletal muscle-specific inducible expression system

Creator:

Xiao, Ying-Yi

Abstract:

The first goal of this study was to understand the role of u-calpain in skeletal muscle protein degradation in cultured muscle cells. Several strategies were developed to down-regulate endogenous u-calpain activity and m-calpain activity in rat myotubes. These included over-expression of antisense u-calpain (AnsL), dominant negative u-calpain (DN-u-CL), antisense 30K...

Resource Type:

Dissertation

Full Text:

Doctor of Philosophy in Animal Science and Molecular & Cellular Biology presented on March 15, 2001