Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Frei, Balz Academic Affiliation Biochemistry and Biophysics Advisor Frei, Balz B.

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Creator:

Li, Chuan

Abstract:

Atherosclerosis is the underlying cause of ischemic heart disease and stroke and is the leading cause of death worldwide, especially in developed countries. As an inflammatory disease of arteries in a hyperlipidemic milieu, expression of adhesion molecules, such as endothelial-leukocyte adhesion molecule-1 (E-selectin) and intercellular adhesion molecule-1 (ICAM-1), on endothelial...

Resource Type:

Dissertation

Full Text:

. Abstract approved: ______________________________________________________ Balz B. Frei
Antioxidant mechanisms of ascorbate and (R)-α-lipoic acid in aging and transition metal ion-mediated oxidative stress

Creator:

Shu, Jung Hyuk

Abstract:

Oxidative stress is the major driving force behind the aging process and many age-related diseases. However, direct experimental evidence of whether antioxidants, such as ascorbate (AA) and lipoic acid (LA) can slow the progression of aging process and/or reduce risks of developing degenerative disease is largely absent. This suggests a...

Resource Type:

Dissertation

Full Text:

Abstract approved: Balz B. Frei c/Tory M.'Hagen Oxidative stress is the major driving force behind the