The interaction of skeletal muscle phosphofructokinase
with a variety of acidic proteins including calmodulin and
troponin C and with nucleic acids (RNA and DNA) is manifest
in a reversible, time-dependent loss of catalytic activity.
The inactivation is affected by a number of factors.
Substrates (fructose-6-phosphate and ATP), positive
effectors (fructose-2,6-bisphosphate,...
This is the first study to explore the ability of an enzyme to recognize and repair
spontaneous age-dependent damage to its own sequence. Protein (D-aspartyl/L-isoaspartyl)
carboxyl methyltransferase (PCM) is known to repair damage that arises
from a spontaneous isomerization of aspartyl and asparaginyl residues in other proteins
during aging. As...