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Creator:: Shu, Jung Hyuk
Abstract:: Oxidative stress is the major driving force behind the aging process and many age-related diseases. However, direct experimental evidence of whether antioxidants, such as ascorbate (AA) and lipoic acid (LA) can slow the progression of aging process and/or reduce risks of developing degenerative disease is largely absent. This suggests a...
Resource Type:: Dissertation
Full Text:: Abstract approved: Balz B. Frei c/Tory M.'Hagen Oxidative stress is the major driving force behind the

Creator:: Michels, Alexander Johannes
Abstract:: Vitamin C is an essential component of the human diet. Uptake of vitamin C in the cell is regulated by the function of sodium-dependent vitamin C transporters (SVCTs). SVCT1 (encoded by the SLC23A1 gene) is expressed in the colon, liver and kidney, where it plays a vital role in determining...
Resource Type:: Dissertation
Full Text:: relationship. I would also like to show my appreciation for my committee members, Drs. Balz Frei, Maret

Creator:: Stoner, Christopher S.
Abstract:: Aerobic organisms have evolved many sensory mechanisms that allow response to oxidants in the environment. One area of interest is the relationship between the activity of the tumor suppressor protein p53 and the redox state of thioredoxin. Human p53 activity is severely compromised in budding yeast lacking thioredoxin reductase. Evidence...
Resource Type:: Dissertation

Creator:: Robinson, Kristine M.
Abstract:: Mutations to superoxide dismutase were the first proven cause of Lou Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in the selective death of motor neurons that characterizes ALS. Nitric oxide competes effectively with superoxide dismutase for superoxide to form the powerful oxidant peroxynitrite. Endogenous formation of peroxynitrite can kill...
Resource Type:: Dissertation

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