Index Catalog // ScholarsArchive@OSU

Creator:: Connolly, Lanelle R., Smith, Kristina M., and Freitag, Michael
Abstract:: The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to humans and animals, yet coordinated transcriptional regulation of gene clusters remains largely a mystery. By chromatin immunoprecipitation and high-throughput DNA sequencing (ChIP-seq) we found that regions with secondary metabolite clusters are enriched for trimethylated histone H3 lysine 27 (H3K27me3), a...
Resource Type:: Article

Creator:: Traeger, Stefanie, Altegoer, Florian, Freitag, Michael, Gabaldon, Toni, Kempken, Frank, Kumar, Abhishek, Marcet-Houben, Marina, Poggeler, Stefanie, Stajich, Jason E., and Nowrousian, Minou
Abstract:: Fungi are a large group of eukaryotes found in nearly all ecosystems. More than 250 fungal genomes have already been sequenced, greatly improving our understanding of fungal evolution, physiology, and development. However, for the Pezizomycetes, an early-diverging lineage of filamentous ascomycetes, there is so far only one genome available, namely...
Resource Type:: Article

Creator:: Mourino-Perez, Rosa R., Linacre-Rojas, Lorena P., Roman-Gavilanes, Ariana I., Lew, Thomas K., Callejas-Negrete, Olga A., Roberson, Robert W., and Freitag, Michael
Abstract:: The microtubule (MT) "plus end" constitutes the platform for the accumulation of a structurally and functionally diverse group of proteins, collectively called "MT plus-end tracking proteins" (+TIPs). +TIPs control MT dynamics and link MTs to diverse sub-cellular structures. Neurospora crassa MicroTubule Binding protein-3 (MTB-3) is the homolog of yeast EB1,...
Resource Type:: Article

Creator:: Vidal-Dupiol, Jeremie, Zoccola, Didier, Tambutté, Eric, Grunau, Christoph, Cosseau, Céline, Smith, Kristina M., Freitag, Michael, Dheilly, Nolwenn M., Allemand, Denis, and Tambutté, Sylvie
Abstract:: Since the preindustrial era, the average surface ocean pH has declined by 0.1 pH units and is predicted to decline by an additional 0.3 units by the year 2100. Although subtle, this decreasing pH has profound effects on the seawater saturation state of carbonate minerals and is thus predicted to...
Resource Type:: Article

Creator:: Saldivar, Joshua C., Miuma, Satoshi, Bene, Jessica, Hosseini, Seyed Ali, Shibata, Hidetaka, Sun, Jin, Wheeler, Linda J., Mathews, Christopher K., and Huebner, Kay
Abstract:: Genomic instability drives tumorigenesis, but how it is initiated in sporadic neoplasias is unknown. In early preneoplasias, alterations at chromosome fragile sites arise due to DNA replication stress. A frequent, perhaps earliest, genetic alteration in preneoplasias is deletion within the fragile FRA3B/FHIT locus, leading to loss of Fhit protein expression....
Resource Type:: Article

Creator:: Ishikawa, Francine H., Souza, Elaine A., Shoji, Jun-ya, Connolly, Lanelle, Freitag, Michael, Read, Nick D., and Roca, M. Gabriela
Abstract:: It has been hypothesized that horizontal gene/chromosome transfer and parasexual recombination following hyphal fusion between different strains may contribute to the emergence of wide genetic variability in plant pathogenic and other fungi. However, the significance of vegetative (heterokaryon) incompatibility responses, which commonly result in cell death, in preventing these processes...
Resource Type:: Article

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