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Filtering by: Creator Kawula, Steven P. Academic Affiliation Biochemistry and Biophysics Degree Level Bachelor's

Impacts of Tertiary Ligands in Catalysis in Thermostable Human Carbonic Anhydrase II by Site-directed Mutagenesis and Genetic Code Expansion

Creator:

Stevens, Danielle M.

Abstract:

Carbonic anhydrases are ubiquitous enzymes that catalyze the reverse hydration and dehydration of carbon dioxide and bicarbonate respectively. A variety of tumors in humans show overexpression of human carbonic anhydrase II (HCA II) leading to an acidic breakdown of carbon dioxide into bicarbonate. While a variety of drug inhibitors exist,...

Resource Type:

Research Paper

Full Text:

phenylalanine with p-bromophenylalanine (pBrF) has a slight decrease in enzymatic activity while the exchange