Index Catalog // ScholarsArchive@OSU

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Creator:: Li, Chuan
Abstract:: Atherosclerosis is the underlying cause of ischemic heart disease and stroke and is the leading cause of death worldwide, especially in developed countries. As an inflammatory disease of arteries in a hyperlipidemic milieu, expression of adhesion molecules, such as endothelial-leukocyte adhesion molecule-1 (E-selectin) and intercellular adhesion molecule-1 (ICAM-1), on endothelial...
Resource Type:: Dissertation
Full Text:: . Abstract approved: ______________________________________________________ Balz B. Frei

Antioxidant mechanisms of ascorbate and (R)-α-lipoic acid in aging and transition metal ion-mediated oxidative stress

Creator:: Shu, Jung Hyuk
Abstract:: Oxidative stress is the major driving force behind the aging process and many age-related diseases. However, direct experimental evidence of whether antioxidants, such as ascorbate (AA) and lipoic acid (LA) can slow the progression of aging process and/or reduce risks of developing degenerative disease is largely absent. This suggests a...
Resource Type:: Dissertation
Full Text:: Abstract approved: Balz B. Frei c/Tory M.'Hagen Oxidative stress is the major driving force behind the

The microtubule system and the canalicular mdr2 P-glycoprotein play a role in the intracellular transport and biliary secretion of α-Tocopherol and phosphatidylcholine in rats and mice

Creator:: Mustacich, Debbie J.
Resource Type:: Dissertation
Full Text:: would like to thank my committee members, Drs. Henry Schaup, Dave Williams, Brad Smith, Balz Frei, and

SLC23A1, the gene encoding sodium-dependent vitamin C transport protein 1 (SVCT1) : regulation of transcription and its functional consequences

Creator:: Michels, Alexander Johannes
Abstract:: Vitamin C is an essential component of the human diet. Uptake of vitamin C in the cell is regulated by the function of sodium-dependent vitamin C transporters (SVCTs). SVCT1 (encoded by the SLC23A1 gene) is expressed in the colon, liver and kidney, where it plays a vital role in determining...
Resource Type:: Dissertation
Full Text:: relationship. I would also like to show my appreciation for my committee members, Drs. Balz Frei, Maret

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:: Monette, Jeffrey S.
Abstract:: Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
Resource Type:: Dissertation
Full Text:: like to thank the members of my graduate committee, Drs. Balz Frei, Joseph Beckman, J. Fred Stevens

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Creator:: Smith, Eric Jonathan
Abstract:: Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...
Resource Type:: Dissertation
Full Text:: would also like to thank my committee for the guidance that led me to this point; Drs. Balz Frei

Mitochondrial decay in the aging rat heart : changes in fatty acid-supported bioenergetics and macromolecular organization of the electron transport system

Creator:: Gómez Ramirez, Luis A.
Abstract:: Decline in cardiac pump function is a hallmark of aging where mitochondrial decay is an important underlying cause. Although certainly multifactorial in nature, both dysfunction of the machinery involved in the chemiosmotic process of energy transduction and lower capacity to maintain fatty acid-driven respiration are identified as intrinsic factors of...
Resource Type:: Dissertation
Full Text:: research committee, Drs. Claudia S. Maier, Balz Frei, Joseph Beckman and Adam Higgins not only for

Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

Creator:: Stoner, Christopher S.
Abstract:: Aerobic organisms have evolved many sensory mechanisms that allow response to oxidants in the environment. One area of interest is the relationship between the activity of the tumor suppressor protein p53 and the redox state of thioredoxin. Human p53 activity is severely compromised in budding yeast lacking thioredoxin reductase. Evidence...
Resource Type:: Dissertation

The detection of superoxide and implications for amyotrophic lateral sclerosis

Creator:: Robinson, Kristine M.
Abstract:: Mutations to superoxide dismutase were the first proven cause of Lou Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in the selective death of motor neurons that characterizes ALS. Nitric oxide competes effectively with superoxide dismutase for superoxide to form the powerful oxidant peroxynitrite. Endogenous formation of peroxynitrite can kill...
Resource Type:: Dissertation

ScholarsArchive@OSU

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Antioxidant mechanisms of ascorbate and (R)-α-lipoic acid in aging and transition metal ion-mediated oxidative stress

The microtubule system and the canalicular mdr2 P-glycoprotein play a role in the intracellular transport and biliary secretion of α-Tocopherol and phosphatidylcholine in rats and mice

SLC23A1, the gene encoding sodium-dependent vitamin C transport protein 1 (SVCT1) : regulation of transcription and its functional consequences

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Mitochondrial decay in the aging rat heart : changes in fatty acid-supported bioenergetics and macromolecular organization of the electron transport system

Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

The detection of superoxide and implications for amyotrophic lateral sclerosis

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