Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Freitag, Camille M. Academic Affiliation Biochemistry and Biophysics Degree Level Master's

Antimicrobial peptide regulation by small molecules in humans and other primates

Creator:

Sinnott, Brian D.

Abstract:

Antimicrobial peptides (AMPs) play an important role in the innate immune system. Determining the pathways by which these proteins are regulated allows for modulation of their expression for better health. Two families of antimicrobial peptides have been studied in humans: cathelicidins and defensins. There is a single cathelicidin in humans...

Resource Type:

Masters Thesis

Full Text:

.............................................................................. 17 5. Q-PCR for CAMP with increasing doses of 1,25(OH)2 D3 with 10-5 M disulfarim in U937 cells
Identifying the Enzymes Responsible for Reduction of Doxorubicin to its Cardiotoxic Metabolite Doxorubicinol using a Novel Immunoclearing Approach

Creator:

Breysse, Daniel H.

Abstract:

Doxorubicin is a widely used cancer therapeutic, but its effectiveness is limited by cardiotoxic side effects. Evidence suggests cardiotoxicity is due not to doxorubicin, but rather its metabolite, doxorubicinol. Identification of the enzymes responsible for doxorubicinol formation is important in developing strategies to prevent cardiotoxicity. In this study, the contributions...

Resource Type:

Masters Thesis

Full Text:

cytosol prepared from 13 pooled mouse livers to achieve a salt solution at 40% of saturation (1.64 M