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Filtering by: Creator Song, Lian Remove constraint Creator: Song, Lian Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.)

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Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Creator:

Baker, Kasie J.

Abstract:

The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...

Resource Type:

Dissertation
Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

Creator:

Estelle, Aidan B.

Abstract:

Interactions between proteins are essential to life, driving and regulating a majority of processes within all living cells. Study of protein-protein interactions reveals that some proteins act as hubs within networks of interactions, binding to many partner proteins. These hubs therefore are of particular importance to understanding protein function, interwoven...

Resource Type:

Dissertation
Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Creator:

Perkins, Arden

Abstract:

Peroxiredoxin (Prx) enzymes catalyze the reduction of hydrogen peroxide, peroxynitrous acid, and organic peroxides, and are extremely efficient peroxidases, with k[subscript cat]/K[subscript M] on the order of 10⁷ - 10⁸ M⁻¹ s⁻¹. Besides their role in oxidative stress defense, evidence has accumulated that some eukaryotes, including humans, use Prxs as...

Resource Type:

Dissertation
Characterization of neuronal nitric-oxide synthase reductase activity

Creator:

Wolthers, Kirsten R.

Abstract:

During catalysis the flavoprotein domain of neuronal nitric-oxide synthase (nNOS) shuttles NADPH-derived reducing equivalents from FAD to FMN and then to the P450-heme enabling heme-based oxygen activation and subsequent NO-synthesis. The binding of Ca²⁺-activated calmodulin (Ca²⁺-CaM) to nNOS alleviates inhibition of flavin mediated electron transfer within the diflavin domain, which...

Resource Type:

Dissertation

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Academic Affiliation

Biochemistry and Biophysics[remove]4

Advisor

Barbar, Elisar1
Karplus, P. Andrew1
Nyarko, Afua A.1
Schimerlik, Michael I.1

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 2001 to 2023

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Committee Member

Anderson, Sonia1
Barbar, Elisar J.1
Bisson, William1
Cooley, Richard1
Giovannoni, Stephen1
more Committee Members »

Creator

Baker, Kasie J.1
Estelle, Aidan B.1
Perkins, Arden1
Wolthers, Kirsten R.1

Date

Date range begin – Date range end

Current results range from 2001 to 2022

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Decade

2020-20292
2010-20191
2000-20091

Degree Field

Biochemistry and Biophysics4

Degree Level

Doctoral4

Degree Name

Doctor of Philosophy (Ph.D.)[remove]4

Language

English [eng]4

License

All rights reserved3

Non-Academic Affiliation

Oregon State University. Graduate School2

Peer Reviewed

No4

Resource Type

Dissertation4

Rights Statement

In Copyright3
Copyright Not Evaluated1

Subject

Antioxidants1
Catalysis1
Conformational analysis1
Crystallography1
Nitric-oxide synthase1
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