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Filtering by: Creator Frei, Balz Academic Affiliation Biochemistry and Biophysics File Format application/pdf

SLC23A1, the gene encoding sodium-dependent vitamin C transport protein 1 (SVCT1) : regulation of transcription and its functional consequences

Creator:

Michels, Alexander Johannes

Abstract:

Vitamin C is an essential component of the human diet. Uptake of vitamin C in the cell is regulated by the function of sodium-dependent vitamin C transporters (SVCTs). SVCT1 (encoded by the SLC23A1 gene) is expressed in the colon, liver and kidney, where it plays a vital role in determining...

Resource Type:

Dissertation

Full Text:

relationship. I would also like to show my appreciation for my committee members, Drs. Balz Frei, Maret
Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

Creator:

Stoner, Christopher S.

Abstract:

Aerobic organisms have evolved many sensory mechanisms that allow response to oxidants in the environment. One area of interest is the relationship between the activity of the tumor suppressor protein p53 and the redox state of thioredoxin. Human p53 activity is severely compromised in budding yeast lacking thioredoxin reductase. Evidence...

Resource Type:

Dissertation
The detection of superoxide and implications for amyotrophic lateral sclerosis

Creator:

Robinson, Kristine M.

Abstract:

Mutations to superoxide dismutase were the first proven cause of Lou Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in the selective death of motor neurons that characterizes ALS. Nitric oxide competes effectively with superoxide dismutase for superoxide to form the powerful oxidant peroxynitrite. Endogenous formation of peroxynitrite can kill...

Resource Type:

Dissertation