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Filtering by: Committee Member Freeman, P. K. Remove constraint Committee Member: Freeman, P. K. Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics Language English [eng] Remove constraint Language: English [eng] Subject Polycyclic aromatic hydrocarbons -- Toxicology Remove constraint Subject: Polycyclic aromatic hydrocarbons -- Toxicology

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  • DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

    Creator:
    Hooven, Louisa Ada
    Abstract:
    Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
    Resource Type:
    Dissertation
    Full Text:
    unwavering support. My appreciation is also extended to Dr. P. Shing Ho, Dr. Christopher K. Mathews, and Dr