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Filtering by: Creator Koo, Dal-Hoe Academic Affiliation Biochemistry and Biophysics Non-Academic Affiliation Oregon State University. Graduate School

The effects of hexachlorophene on mitochondrial and artificial membrane systems

Creator:

Ramberg, Donald Allen

Abstract:

Hexachlorophene (HCP; 2,2'-methylenebis-(3,4,6-trichlorophenol)) was developed as an antibacterial agent but was also found to induce toxic effects in various tissues in animals and humans. Changes were found in myelinated nerve fibers and cerebral white matter. Erythrocytes are hemolysed in vitro. Oxidative phosphorylation is uncoupled by HCP at concentrations less than...

Resource Type:

Dissertation

Full Text:

HCP can be protected against by benzodiazepine (Yen- Koo and Davis, 1973). Intravenous urea-sugar
Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

Creator:

Roberts, Blaine R.

Abstract:

Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...

Resource Type:

Dissertation
Building a bridge from chromosomes to microtubules in Neurospora crassa

Creator:

Friedman, Steven

Abstract:

DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...

Resource Type:

Dissertation