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Filtering by: Committee Member Qiu, Weihong Remove constraint Committee Member: Qiu, Weihong Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics

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  • In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

    Creator:
    Blizzard, Robert J.
    Abstract:
    The inverse electron demand Diels Alder reaction between tetrazines and strained alkenes is an exceptionally useful tool in functionalizing to biomolecules since it is orthogonal to the chemistry of most living systems and have exceptionally high rate constants. In particular reactions between strained trans-cyclooctenes (sTCO) and tetrazines can achieve second...
    Resource Type:
    Dissertation

  • Single-molecule in vitro Characterization of Otoferlin

    Creator:
    Hams, Nicole J.
    Abstract:
    Congenital hearing loss is a common disorder and over 60 mutations in the sensory hair cell protein, otoferlin, have been linked to pre-lingual deafness. Although otoferlin is essential for hearing, the large size and low solubility of the protein have limited approaches to study its function on a molecular-level. To...
    Resource Type:
    Dissertation
    Full Text:
    members, Dr. Elisar Barbar, Dr. Kate Schilke, Dr. Victor Hsu and Dr. Weihong Qiu, as well as Dr. Ryan

  • Exploring Protein Structure: Seeing the Forest and the Trees

    Creator:
    Brereton, Andrew E.
    Abstract:
    Life on Earth intimately depends on the function of countless proteins. For the majority of studied proteins, function absolutely depends on conformation (i.e. 3-dimensional shape in solution). The exact nature of how a protein goes from an unfolded linear polypeptide chain to an organized folded molecule is still not known,...
    Resource Type:
    Dissertation

  • Initial in vitro and in vivo Characterization of the Membrane Trafficking Protein Fer1L6

    Creator:
    Wolk, Chelsea
    Abstract:
    A fundamental difference between prokaryotic and eukaryotic cells is the presence of membrane bound organelles in eukaryotes. The dynamics of membrane trafficking within the cell are responsible for everything from intercellular communication and cell homeostasis, to mitosis, cell migration, and differentiation. These processes require exocytosis and compensatory endocytosis, often working...
    Resource Type:
    Dissertation
    Full Text:
    . Weihong Qiu, and Dr. David  Hendrix.    Also, this type of graduate work would not be possible without

  • Protein Disorder in the Evolution of Dynein Regulation

    Creator:
    Jie, Jing
    Abstract:
    Intrinsically disordered proteins (IDP) are a class of proteins that lack a three-dimensional structure and their prevalence and diverse functions in the cell have only been discovered relatively recently. The intermediate chain (IC) subunit of the microtubule motor protein complex dynein contains an N-terminal disordered region, N-IC, which is central...
    Resource Type:
    Dissertation
    Full Text:
    committee members, past and present, Dr. Andrew Karplus, Dr. Gary Merrill, Dr. Weihong Qiu, Dr. Barbara

  • Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

    Creator:
    Baker, Kasie J.
    Abstract:
    The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
    Resource Type:
    Dissertation
    Full Text:
    . I would like to thank my committee members Dr. Barbar, Dr. Johnson, Dr. Qiu, and Dr. Taylor for

  • Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

    Creator:
    Narayanappa, Murugesh
    Abstract:
    Hearing loss is one of the most common defect, affecting 360 million people worldwide due to several factors including congenital, present at or soon after birth or acquired with age. Congenital hearing loss affects 32 million children in the world. The economic impact of hearing loss is estimated to cost...
    Resource Type:
    Dissertation
    Full Text:
    . I definitely wouldn’t have kept my sanity without it. I thank my committee members Weihong