Index Catalog // ScholarsArchive@OSU

CRP1, a Protein Localized in Filopodia of Growth Cones, Is Involved in Dendritic Growth

Creator:: Ma, Liping, Greenwood, Jeffrey A., and Schachner, Melitta
Abstract:: The cysteine-rich protein (CRP) family is a subgroup of LIM domain proteins. CRP1, which cross-links actin filaments to make actin bundles, is the only CRP family member expressed in the CNS with little known about its function in nerve cells. Here, we report that CRP1 colocalizes with actin in the...
Resource Type:: Article

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation

Evaluating peroxiredoxin sensitivity towards inactivation by peroxide substrates

Creator:: Nelson, Kimberly J., Parsonage, Derek, Karplus, P. Andrew, and Poole, Leslie B.
Abstract:: Peroxiredoxins (Prxs) are very effective peroxide reducing enzymes, but also are susceptible to being oxidatively inactivated by their own substrates. The level of sensitivity to such hyperoxidation varies depending both on the enzyme involved and the type of peroxide substrate. For some Prxs, the hyperoxidation has physiological relevance, so it...
Resource Type:: Article
Full Text:: . Y., Han, S. H., Sung, S. H., Lee, H. E., Kim, Y. M., Noh, Y. H., Bae, S. H., Rhee, S. G., and Chang

Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

Creator:: Stoner, Christopher S.
Abstract:: Aerobic organisms have evolved many sensory mechanisms that allow response to oxidants in the environment. One area of interest is the relationship between the activity of the tumor suppressor protein p53 and the redox state of thioredoxin. Human p53 activity is severely compromised in budding yeast lacking thioredoxin reductase. Evidence...
Resource Type:: Dissertation

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Creator:: Perkins, Arden
Abstract:: Peroxiredoxin (Prx) enzymes catalyze the reduction of hydrogen peroxide, peroxynitrous acid, and organic peroxides, and are extremely efficient peroxidases, with k[subscript cat]/K[subscript M] on the order of 10⁷ - 10⁸ M⁻¹ s⁻¹. Besides their role in oxidative stress defense, evidence has accumulated that some eukaryotes, including humans, use Prxs as...
Resource Type:: Dissertation

Biosyntheis of Blasticidin S : pathway and enzymes for the nucleoside formation and blastidic acid assembly

Creator:: Guo, Jincan
Resource Type:: Dissertation
Full Text:: , 1981, 655, 335-341. 6. Woo, N-T. M.S Thesis, Oregon State University. 1985. 7. Shomura, T.; Inoue, M

Characterization of the Zea mays ssp. mays TOUSLED-like kinases

Creator:: Owusu, Ethel Owusuwaa
Abstract:: This dissertation describes the cloning and characterization of the TOUSLEDlike kinases genes of maize (ZmTLKs). The TOUSLED-like kinases (TLKs) are a conserved family of nuclear Ser/Thr kinases in higher eukaryotes. The maize genome has three TOUSLED-like kinase genes (ZmTLK1, ZmTLK2, and ZmTLK3). Based upon sequence similarity, the ZmTLKs are divided...
Resource Type:: Dissertation
Full Text:: (Carrera et al., 2003) and Caenorhabditis elegans (Han et al., 2003). TSL has a unique kinase domain

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Creator:: Li, Chuan
Abstract:: Atherosclerosis is the underlying cause of ischemic heart disease and stroke and is the leading cause of death worldwide, especially in developed countries. As an inflammatory disease of arteries in a hyperlipidemic milieu, expression of adhesion molecules, such as endothelial-leukocyte adhesion molecule-1 (E-selectin) and intercellular adhesion molecule-1 (ICAM-1), on endothelial...
Resource Type:: Dissertation
Full Text:: damage to cardiomyocytes from rats [Woo 2008]. GR is another important enzyme involved in maintaining

The Genome and Development-Dependent Transcriptomes of Pyronema confluens: A Window into Fungal Evolution

Creator:: Traeger, Stefanie, Altegoer, Florian, Freitag, Michael, Gabaldon, Toni, Kempken, Frank, Kumar, Abhishek, Marcet-Houben, Marina, Poggeler, Stefanie, Stajich, Jason E., and Nowrousian, Minou
Abstract:: Fungi are a large group of eukaryotes found in nearly all ecosystems. More than 250 fungal genomes have already been sequenced, greatly improving our understanding of fungal evolution, physiology, and development. However, for the Pezizomycetes, an early-diverging lineage of filamentous ascomycetes, there is so far only one genome available, namely...
Resource Type:: Article

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Creator:: Nian, Hui
Abstract:: Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
Resource Type:: Dissertation

Toxicity and in vitro metabolism of Senecio jacobaea pyrrolizidine alkaloids in the rat and mouse

Creator:: Ramsdell, Howard Scott
Abstract:: Senecio jacobaea (tansy ragwort) is a common weed in the Pacific Northwest that contains toxic pyrrolizidine alkaloids (PAs). Jacobine, the major PA in Senecio jacobaea, was incubated with rat liver microsomes and metabolites were isolated by high performance liquid chromatography (HPLC) and identified by mass spectrometric analysis. Metabolites included a...
Resource Type:: Dissertation

ScholarsArchive@OSU

CRP1, a Protein Localized in Filopodia of Growth Cones, Is Involved in Dendritic Growth

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Evaluating peroxiredoxin sensitivity towards inactivation by peroxide substrates

Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Biosyntheis of Blasticidin S : pathway and enzymes for the nucleoside formation and blastidic acid assembly

Characterization of the Zea mays ssp. mays TOUSLED-like kinases

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

The Genome and Development-Dependent Transcriptomes of Pyronema confluens: A Window into Fungal Evolution

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Toxicity and in vitro metabolism of Senecio jacobaea pyrrolizidine alkaloids in the rat and mouse

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