Index Catalog // ScholarsArchive@OSU

Creator:: Kyme, Pierre, Thoennissen, Nils H., Tseng, Ching Wen, Thoennissen, Gabriela B., Wolf, Andrea J., Shimada, Kenichi, Krug, Utz O., Lee, Kunik, Muller-Tidow, Carsten, Berdel, Wolfgang E., Hardy, W. David, Gombart, Adrian F., Koeffler, H. Phillip, and Liu, George Y.
Abstract:: The myeloid-specific transcription factor, CCAAT/enhancer-binding protein epsilon (C/EBPε) is a critical mediator of myelopoiesis. Mutation of this gene is responsible for neutrophil-specific granule deficiency in humans, a condition that confers susceptibility to Staphylococcus aureus infection. We found that C/EBPε-deficient mice are severely affected by infection with S. aureus, and C/EBPε...
Resource Type:: Article
Full Text:: . doi:10.1172/JCI62070. research article The Journal of Clinical Investigation http://www.jci.org

Creator:: Roquis, David, Lepesant, Julie M. J., Picard, Marion A. L., Freitag, Michael, Parrinello, Hugues, Groth, Marco, Emans, Rémi, Cosseau, Céline, and Grunau, Christoph
Abstract:: Background: Chromatin structure can control gene expression and can define specific transcription states. For example, bivalent methylation of histone H3K4 and H3K27 is linked to poised transcription in vertebrate embryonic stem cells (ESC). It allows them to rapidly engage specific developmental pathways. We reasoned that non-vertebrate metazoans that encounter a...
Resource Type:: Article

Creator:: Riordan, Ruben
Abstract:: Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
Resource Type:: Dissertation

Creator:: Logan, Isabelle E.
Abstract:: Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...
Resource Type:: Dissertation

Creator:: Gamble, John T.
Abstract:: The goal of this dissertation was to improve our abilities in acquiring critical in vivo data by establishing embryo-larva zebrafish as an exemplary model to quantitatively evaluate cancer progression. The living environment that encompasses a tumor has a significant effect on how cancer develops, grows and metastasizes. In order to...
Resource Type:: Dissertation

Creator:: Thomas, Nicholas O.
Abstract:: Over the past century, life expectancy in the United States has dramatically increased leading to an increasingly aging population with people reaching, and spending more years in ‘old age’. While this unprecedented shift in population demographics represents great strides for humanity, it is not without cost. One consequence of longer...
Resource Type:: Dissertation

ScholarsArchive@OSU