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Filtering by: Creator Bailey, Brian N. Remove constraint Creator: Bailey, Brian N. Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics

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  • Cloning, sequencing and aflatoxin B₁ metabolism by multiple rainbow trout CYP1A cDNAs expressed in yeast

    Creator:
    You, Lijing
    Abstract:
    Previous reports indicate the presence of multiple CYP1A sequences in rainbow trout, but their functional differences are unknown. This report describes the cloning and partial characterization of four trout CYP1A cDNAs, which are given the tentative designations CYP1A1v2, v3, v4, and v5. Comparison among these four and three previously reported...
    Resource Type:
    Masters Thesis
    Full Text:
    approved: George Bailey Previous reports indicate the presence of multiple CYP1A sequences in rainbow

  • Analysis of ras gene mutations in rainbow trout tumors

    Creator:
    Chang, Yung-jin
    Abstract:
    For ras gene mutation analysis in the rainbow trout (Oncorhynchus mykiss) model system, a partial trout ras sequence was identified using the polymerase chain reaction (PCR). Two synthetic oligonucleotides based on rat K-ras gene sequence were used as primers for the PCR procedure. A 90 base pair (bp) sequence, referred...
    Resource Type:
    Dissertation
    Full Text:
    Tumors. Abstract approved : Redacted for Privacy George S. Bailey For ras gene mutation analysis in

  • Site-specific aflatoxin B₁ adduction of sequence-positioned nucleosome core particles

    Creator:
    Moyer, Richard A.
    Abstract:
    The question of how the presence of nucleosomal packing of DNA modifies carcinogen interaction at specific sites cannot be answered by studies on whole chromatin or bulk nucleosomes because of the heterogeneity of DNA sequences in the particles. This problem was circumvented by constructing nucleosomes that are homogenous in DNA-histone...
    Resource Type:
    Dissertation
    Full Text:
    privacy George T. Bailey The question of how the presence of nucleosomal packing of DNA modifies

  • An integrative approach to understanding pyoluteorin biosynthesis in the biological control bacterium Pseudomonas fluorescens Pf-5

    Creator:
    Nowak-Thompson, Brian
    Resource Type:
    Dissertation
    Full Text:
    OF Brian Nowak-Thompson for the degree of Doctor of Philosophy in Biochemistry and Biophysics

  • Antimicrobial peptide regulation by small molecules in humans and other primates

    Creator:
    Sinnott, Brian D.
    Abstract:
    Antimicrobial peptides (AMPs) play an important role in the innate immune system. Determining the pathways by which these proteins are regulated allows for modulation of their expression for better health. Two families of antimicrobial peptides have been studied in humans: cathelicidins and defensins. There is a single cathelicidin in humans...
    Resource Type:
    Masters Thesis
    Full Text:
    THESIS OF Brian D. Sinnott for the degree of Master of Science in Biochemistry and Biophysics

  • Incorporation of chromatophores into multi-cellular biosensors

    Creator:
    Preston, R. Ryan
    Abstract:
    Methodologies that detect biologically active substances have important potential applications for medical diagnostics, drug discovery, and chemical and biological anti-terrorism efforts. The wide spectrum of potential analytes that induce a physiological response dictates that novel techniques be developed to more rapidly screen and characterize agents that are more economical and...
    Resource Type:
    Dissertation
    Full Text:
    : Incorporation of Chromatophores into Multi-Cellular Biosensors. Abstract approved: Philip N. McFadden

  • Automethylation : a response to enzyme aging

    Creator:
    Lindquist, Jonathan A.
    Abstract:
    This is the first study to explore the ability of an enzyme to recognize and repair spontaneous age-dependent damage to its own sequence. Protein (D-aspartyl/L-isoaspartyl) carboxyl methyltransferase (PCM) is known to repair damage that arises from a spontaneous isomerization of aspartyl and asparaginyl residues in other proteins during aging. As...
    Resource Type:
    Dissertation
    Full Text:
    approved: Philip N. McFadden This is the first study to explore the ability ofan enzyme to recognize

  • Crystallographic studies of Pyrenophora tritici-repentis ToxA

    Creator:
    Sarma, Ganapathy N.
    Abstract:
    Tan spot of wheat is an economically significant disease caused by the fungal pathogen, Pyrenophora tritici-repentis. Certain races of the fungus secrete Ptr ToxA (ToxA), a 13.2 kDa proteinaceous host-selective toxin that is responsible and sufficient to cause disease in susceptible wheat varieties. Disease symptoms develop only when the ToxA...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE THESIS OF Ganapathy N. Sarma for the degree

  • Viral Targeting of Host Hubs: Interactions between the Rabies Virus and LC8

    Creator:
    Jespersen, Nathan E.
    Abstract:
    As obligate intracellular parasites, viruses rely on host machinery for their own reproduction. Viruses are therefore required to interact with a wide variety of host proteins, despite limitations in viral genome size. The most parsimonious method of success is to hijack central and essential proteins, known as hub proteins. LC8...
    Resource Type:
    Dissertation
    Full Text:
    some of the finer points of my fellowship application. Dr. Brian Dolan, you saved the day by agreeing

  • Studies of rainbow trout Ki-ras gene : sequencing, aflatoxin B1 binding, and chromatin structure

    Creator:
    Liang, Xiaoshan
    Abstract:
    Characterization of the 5' flanking region of rainbow trout ki-ras gene was begun with the cloning and sequencing of this region by the inverse PCR technique and dideoxynucleotide chain termination method. In total, a nucleotide sequence of 1080 bp upstream from the first coding ATG was sequenced. Although this region...
    Resource Type:
    Dissertation
    Full Text:
    Bailey, for his instruction and advice on the academic problems, and for being my committee member. Dr