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Filtering by: Creator Bernert, Joseph A. Academic Affiliation Biochemistry and Biophysics

Nitric oxide-mediated oxidative damage and the progressive demise of motor neurons in ALS

Creator:

Drechsel, Derek A., Estevez, Alvaro G., Barbeito, Luis, and Beckman, Joseph S.

Abstract:

Oxidative damage is a common and early feature of Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Dr. Mark Smith and his colleagues have built the case for oxidative stress being a primary progenitor rather than a secondary end-stage epiphenomenon of neurodegeneration. They proposed that reactive...

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, Luis Barbeito d,e , and Joseph S. Beckman b,f,* a Department of Environmental and Molecular
Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C‐MYC depletion

Creator:

Mannava, Sudha, Moparthy, Kalyana C., Wheeler, Linda J., Leonova, Katerina I., Wawrzyniak, Joseph A., Bianchi-Smiraglia, Anna, Berman, Albert E., Flanagan, Sheryl, Shewach, Donna S., Zeitouni, Nathalie C., Gudkov, Andrei V., Mathews, Christopher K., and Nikiforov, Mikhail A.

Abstract:

The down‐regulation of dominant oncogenes, including C‐MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC‐depleted melanoma cells undergo extensive DNA damage that is caused by the underexpression of thymidylate synthase (TS) and ribonucleotide...

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Article

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J. Wheeler3, Katerina I. Leonova1, Joseph A. Wawrzyniak1, Anna Bianchi‐Smiraglia1, Albert E

ScholarsArchive@OSU

Nitric oxide-mediated oxidative damage and the progressive demise of motor neurons in ALS

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C‐MYC depletion

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