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Vaccinia virus ribonucleotide reductase : regulation of the gene products and characterization of the recombinant small subunit protein

Creator:: Howell, Meredith L.
Abstract:: Ribonucleotide reductase is a remarkable enzyme that catalyzes the rate-limiting step in the synthesis of the 2'-deoxynucleoside triphosphates. The intent of this project was to characterize the ribonucleotide reductase encoded by the orthopoxvirus, vaccinia. The first objective was to study the structural and functional features of the viral small subunit...
Resource Type:: Dissertation
Full Text:: / zN \ rN His 241 G lu 115 Figure II.3 Spatial Arrangement of the Binuclear Iron Center in the E

Understanding Circadian and Light-activated Transcriptional Regulatory Changes During Aging in Drosophila melanogaster

Creator:: Fey, Rosalyn M.
Abstract:: Systems biology is a powerful approach which considers and sheds light on all of the puzzle pieces which make up complex biological processes, and is an effective alternative to unraveling these processes using traditional molecular approaches alone. It is a natural companion approach for computational biology, which leverages the power...
Resource Type:: Dissertation
Full Text:: . . . . . . . . . . . . . . . . . . . . . 106 This work is dedicated to my husband, Peter G. Fey. Peter—I can’t begin to thank you enough

Studies on DNA precursor metabolism in vaccinia virus-infected mamalian cells

Creator:: Spiro, Craig
Abstract:: Vaccinia virus-infected animal cells have been used to study the interactions between the replication of deoxyribonucleic acid (DNA) and the biosynthesis of its nucleotide precursors. Some antimetabolites that inhibit DNA replication have as their targets enzymes of nucleotide biosynthesis. Furthermore, the disruption of nucleotide metabolism can alter the fidelity of...
Resource Type:: Dissertation
Full Text:: concentrated in cellular compartments (Fridland, 1973; Skoog and Bjurse11,1974; Bestwick et al.,1982). In

Repression of dihydrofolate reductase synthesis during myogenesis : identification and characterization of a transcriptional regulatory mechanism

Creator:: Schmidt, Edward Eric
Resource Type:: Dissertation
Full Text:: 145 APPENDIX A: APPENDIX B: APPENDIX C: APPENDIX D: APPENDIX E: APPENDIX F: APPENDIX G

Properties and conformation of P-form DNA

Creator:: Zehfus, Micheal H.
Abstract:: Work is presented which explores the properties and nature of the P-form of DNA. Initially the P-form represented an unknown state of DNA which occurred when this molecule was in a solvent of 47.5% methanol, 5% water, and 47.5% ethanol, and which showed properties of both native and denatured conformations....
Resource Type:: Dissertation
Full Text:: were gron in a medium containing M9 salts (6g/1 Na2HPO4, 3g/1 KH2PO4, 0.5 g/1 NaCl, 1g/1 NH4C1 and 0.1

Organization of the T4 dNTP synthetase complex at DNA replication sites

Creator:: Kim, JuHyun
Abstract:: With respect to a multienzyme complex of deoxyribonucleoside triphosphate (dNTP) synthesis somehow juxtaposed with DNA replication sites, our laboratory has demonstrated the existence of a multienzyme complex in T4-infected E. coli, named the T4 dNTP synthetase complex, but the idea of direct linkage of dNTP synthesis to DNA replication and...
Resource Type:: Dissertation
Full Text:: ; Brush and Bessman, 1993; Teplyakov et al., 1996). 3 ADP UDP CI?P G?P Ribonucleotide reductase (RNR

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Creator:: Wang, Yeong
Abstract:: Bacteriophage T4 gene 42 encodes dCMP hydroxymethylase, an enzyme unique to the deoxyribonucleotide metabolism of T-even bacteriophages. To study biochemical and biophysical properties of the enzyme, as well as the interaction of dCMP hydroxymethylase with other DNA precursor biosynthetic enzymes in vitro, availability of large amounts of the enzyme is...
Resource Type:: Dissertation
Full Text:: deoxynucleotide biosynthesis complex. In 1970s, the research groups of C. K. Mathews and G. R. Greenberg first

Insights into mammalian DNA replication from analysis of mutations affecting deoxyribonucleotide biosynthesis

Creator:: Mun, Byung-joo
Abstract:: Although the synthesis of DNA precursors is closely coordinated with DNA replication, it is still not clear whether deoxyribonucleoside triphosphates (dNTPs) influence DNA replication independently of their interactions with DNA polymerase catalytic sites. In an effort to understand the extent to which rate and fidelity of DNA replication are regulated...
Resource Type:: Dissertation
Full Text:: mitochondria, sub- strates for the mitochondrial DNA polymerase. Our lab- oratory (Bestwick et al., 1982

Host kinases involved in DNA precursor biosynthesis during bacteriophage T4 infection

Creator:: Bernard, Mark Aguirre
Abstract:: Although the Escherichia coli host has almost all of the enzymes necessary to synthesize nucleotides needed for bacteriophage T4 DNA replication, phage genes expressed early in infection encode enzymes for de novo DNA precursor biosynthesis and salvage from degraded host DNA. Eight early enzymes and two host enzymes comprise the...
Resource Type:: Dissertation
Full Text:: kinase 19 G-proteins and signal transduction 20 NDP kinase interactions with G-proteins 21 Prokaryotic G

DNA precursor compartmentation in mammalian cells : distribution and rates of equilibration between nucleus and cytoplasm

Creator:: Leeds, Janet M.
Abstract:: A rapid nuclear isolation technique was adapted in order to examine the question of DNA precursor compartmentation in mammalian cells. By using this method a reproducible proportion of the cellular nucleotides remained associated with the isolated nuclei. Examination, at several different cell densities, of exponentially growing HeLa cells showed that...
Resource Type:: Dissertation
Full Text:: ; and 3, dihydrofolate reductase. Fig.1.1 G U il J- UMP CTP0 it UTP UDP C P reductase 1 dUDP

ScholarsArchive@OSU

Vaccinia virus ribonucleotide reductase : regulation of the gene products and characterization of the recombinant small subunit protein

Understanding Circadian and Light-activated Transcriptional Regulatory Changes During Aging in Drosophila melanogaster

Studies on DNA precursor metabolism in vaccinia virus-infected mamalian cells

Repression of dihydrofolate reductase synthesis during myogenesis : identification and characterization of a transcriptional regulatory mechanism

Properties and conformation of P-form DNA

Organization of the T4 dNTP synthetase complex at DNA replication sites

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Insights into mammalian DNA replication from analysis of mutations affecting deoxyribonucleotide biosynthesis

Host kinases involved in DNA precursor biosynthesis during bacteriophage T4 infection

DNA precursor compartmentation in mammalian cells : distribution and rates of equilibration between nucleus and cytoplasm

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